Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19899747 | 0.83 | HRH3 (0.37) | HRH3IRAK4P2RY1 | |
| SCHEMBL31493447 | 0.83 | HRH3 (0.37) | HRH3IRAK4P2RY1 | |
| SCHEMBL1661700 | 0.74 | MAPT (0.41) | — | |
| SCHEMBL30807050 | 0.74 | MAPT (0.41) | — | |
| SCHEMBL31119786 | 0.69 | IRAK4 (0.43) | IRAK4P2RY1 | |
| SCHEMBL22392573 | 0.69 | IRAK4 (0.43) | IRAK4P2RY1 | |
| SCHEMBL35211844 | 0.69 | HRH3 (0.41) | HRH3IRAK4 | |
| SCHEMBL12042139 | 0.69 | HRH3 (0.41) | HRH3IRAK4 | |
| SCHEMBL1661557 | 0.68 | NPC1 (0.43) | — | |
| SCHEMBL1661555 | 0.68 | CA2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709480-A1 | 5,6-FUSED BICYCLIC AMIDES AND COMPOSITIONS FOR USE AS 15-PROSTAGLANDIN DEHYDROGENASE MODULATORS | Amgen Inc. (US) | 2026-03-18 | — | — | EP | disclosed |