SCHEMBL32686385

SCHEMBL32686385

Cn1cnnc1Cc1cc(Cl)nc(Cl)c1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 0.40
HTR2C P28335 1/20 0.40
CBLB Q13191 6/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32686371 0.84 HTR1A (0.34) HTR1AHTR2CCBLB
SCHEMBL25179686 0.80 HTR1A (0.38) HTR1AHTR2CLMNA
SCHEMBL30374388 0.78 HTR1A (0.37) HTR1AHTR2CLMNA
SCHEMBL25180165 0.78 HTR1A (0.37) HTR1AHTR2CLMNA
SCHEMBL25186525 0.77 HTR1A (0.40) HTR1AHTR2CCBLBLMNA
SCHEMBL21201206 0.74 CBLB (0.46) CBLB
SCHEMBL27086221 0.74 CBLB (0.46) CBLB
SCHEMBL21201205 0.74 CBLB (0.46) CBLB
SCHEMBL29238319 0.73 HTR1A (0.42) HTR1AHTR2CLMNA
SCHEMBL25182795 0.71 HTR1A (0.37) HTR1AHTR2CLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709718-A1 6-SUBSTITUTED-3-PHENYL-ISOINDOLIN-1-ONES AS CBL-B INHIBITORS SELECTIVE OVER C-CBL Genentech Inc. (US) 2026-03-18 EP disclosed