Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 15/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HEXA | P06865 | 1/20 | 0.40 |
| ▸ | HEXB | P07686 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3269134 | 0.99 | DHFR (0.49) | DHFRNR4A2MEN1SLC22A1ALDH1A1 | |
| SCHEMBL3266923 | 0.87 | DHFR (0.49) | DHFR | |
| Hydrochloric Acid SCHEMBL3273660 | 0.86 | DHFR (0.49) | DHFR | |
| SCHEMBL3271737 | 0.84 | DHFR (0.58) | DHFRHEXAHEXB | |
| Hydrochloric Acid SCHEMBL3267531 | 0.84 | DHFR (0.57) | DHFRHEXAHEXB | |
| SCHEMBL31155815 | 0.77 | DHFR (0.52) | DHFRMEN1SLC22A1ALDH1A1LMNA | |
| SCHEMBL31155890 | 0.75 | DHFR (0.48) | DHFR | |
| SCHEMBL31155816 | 0.75 | DHFR (0.48) | DHFR | |
| SCHEMBL31155846 | 0.73 | DHFR (0.75) | DHFR | |
| Hydrochloric Acid SCHEMBL11183905 | 0.73 | DHFR (0.78) | DHFRMEN1SLC22A1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3546452-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MMV Medicines for Malaria Venture (CH) | 2019-10-02 | — | — | EP | claimed |
| US-8530491-B2 | Antimalarial compounds with flexible side-chains | MEDICINES FOR MALARIA VENTURE (MMV) (CH) | 2013-09-10 | — | — | US | claimed |
| EP-3546452-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MMV Medicines for Malaria Venture (CH) | 2019-10-02 | — | — | EP | disclosed |
| EP-3546452-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MMV Medicines for Malaria Venture (CH) | 2019-10-02 | — | — | EP | disclosed |
| EP-2194985-B1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2019-02-20 | — | — | EP | disclosed |
| EP-2194985-B1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2019-02-20 | — | — | EP | disclosed |
| US-8530491-B2 | Antimalarial compounds with flexible side-chains | MEDICINES FOR MALARIA VENTURE (MMV) (CH) | 2013-09-10 | — | — | US | disclosed |
| US-8530491-B2 | Antimalarial compounds with flexible side-chains | MEDICINES FOR MALARIA VENTURE (MMV) (CH) | 2013-09-10 | — | — | US | disclosed |
| US-8530491-B2 | Antimalarial compounds with flexible side-chains | MEDICINES FOR MALARIA VENTURE (MMV) (CH) | 2013-09-10 | — | — | US | disclosed |
| EP-2194985-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | Medicines for Malaria Venture (CH) | 2010-06-16 | — | — | EP | disclosed |
| US-20090099220-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MEDICINES FOR MALARIA VENTURE | 2009-04-16 | — | — | US | disclosed |
| WO-2009048957-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | MEDICINES FOR MALARIA VENTURE (CH) | 2009-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099220-A1 | ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS | DHFR, FPGS, DHODH | DHFR 1/4885NR4A2 4278/4885MEN1 4347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.