Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 19/20 | 0.50 |
| ▸ | MERTK | Q12866 | 19/20 | 0.50 |
| ▸ | TYRO3 | Q06418 | 14/20 | 0.50 |
| ▸ | MET | P08581 | 19/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1944223 | 0.95 | AXL (0.55) | AXLMERTKTYRO3MET | |
| SCHEMBL1944230 | 0.95 | AXL (0.53) | AXLMERTKTYRO3MET | |
| SCHEMBL1944232 | 0.95 | AXL (0.53) | AXLMERTKTYRO3MET | |
| SCHEMBL1944226 | 0.95 | AXL (0.55) | AXLMERTKTYRO3MET | |
| SCHEMBL1944677 | 0.91 | AXL (0.53) | AXLMERTKTYRO3MET | |
| SCHEMBL1943791 | 0.89 | MET (0.55) | AXLMERTKTYRO3MET | |
| SCHEMBL1945762 | 0.87 | AXL (0.50) | AXLMERTKTYRO3MET | |
| SCHEMBL1945763 | 0.87 | AXL (0.50) | AXLMERTKTYRO3MET | |
| SCHEMBL1944485 | 0.86 | AXL (0.51) | AXLMERTKTYRO3MET | |
| SCHEMBL1945962 | 0.86 | AXL (0.51) | AXLMERTKTYRO3MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193130-A1 | PYRAZOLO-PYRIDINES AS TYROSINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009033084-A1 | PYRAZOLO-PYRIDINES AS TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-03-12 | — | — | WO | disclosed |