Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 15/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645963 | 0.88 | KIF11 (0.83) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL645675 | 0.86 | KIF11 (0.71) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL644347 | 0.86 | KIF11 (0.71) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL644192 | 0.84 | KIF11 (0.68) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL645666 | 0.81 | KIF11 (0.69) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL643695 | 0.81 | KIF11 (0.69) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL646934 | 0.80 | KIF11 (0.60) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL646350 | 0.79 | KIF11 (0.59) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL645195 | 0.79 | KIF11 (0.59) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL644766 | 0.79 | KIF11 (0.59) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511734-B1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2010-06-23 | — | — | EP | disclosed |