Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.76 |
| ▸ | KDR | P35968 | 8/20 | 0.76 |
| ▸ | FLT4 | P35916 | 4/20 | 0.76 |
| ▸ | KIT | P10721 | 2/20 | 0.69 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.62 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273838 | 0.91 | ALK (0.79) | FLT3KDRFLT4KITALK | |
| SCHEMBL6585195 | 0.88 | KDR (0.67) | FLT3KDRFLT4KITALK | |
| SCHEMBL6585951 | 0.88 | KDR (0.76) | FLT3KDRFLT4KITALK | |
| SCHEMBL3271916 | 0.88 | KDR (0.67) | FLT3KDRFLT4KITALK | |
| SCHEMBL6587955 | 0.88 | ALK (0.83) | FLT3KDRFLT4KITALK | |
| SCHEMBL24166735 | 0.88 | KDR (0.64) | FLT3KDRFLT4KITALK | |
| SCHEMBL3268878 | 0.88 | KDR (0.76) | FLT3KDRFLT4KITALK | |
| SCHEMBL3268874 | 0.88 | ALK (0.83) | FLT3KDRFLT4KITALK | |
| SCHEMBL31727049 | 0.88 | KDR (0.67) | FLT3KDRFLT4KITALK | |
| SCHEMBL3798589 | 0.86 | KDR (0.70) | FLT3KDRFLT4KITALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029580-B1 | NOVEL INDOL-PYRROL DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE AND INFLAMMATORY DISEASES | SCHEBO BIOTECH AG (DE) | 2010-06-16 | — | — | EP | claimed |