Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.83 |
| ▸ | KDR | P35968 | 8/20 | 0.67 |
| ▸ | FLT3 | P36888 | 7/20 | 0.67 |
| ▸ | FLT4 | P35916 | 4/20 | 0.67 |
| ▸ | KIT | P10721 | 2/20 | 0.67 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.66 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3268874 | 1.00 | ALK (0.83) | ALKKDRFLT3FLT4KIT | |
| SCHEMBL859966 | 0.91 | ALK (1.00) | ALKKDRFLT3FLT4KIT | |
| SCHEMBL859965 | 0.91 | ALK (1.00) | ALKKDRFLT3FLT4KIT | |
| SCHEMBL3273702 | 0.88 | FLT3 (0.76) | ALKKDRFLT3FLT4KIT | |
| SCHEMBL6585951 | 0.86 | KDR (0.76) | ALKKDRFLT3FLT4KIT | |
| SCHEMBL3271916 | 0.86 | KDR (0.67) | ALKKDRFLT3FLT4KIT | |
| SCHEMBL6585195 | 0.86 | KDR (0.67) | ALKKDRFLT3FLT4KIT | |
| SCHEMBL3268878 | 0.86 | KDR (0.76) | ALKKDRFLT3FLT4KIT | |
| SCHEMBL31727049 | 0.86 | KDR (0.67) | ALKKDRFLT3FLT4KIT | |
| SCHEMBL2111248 | 0.86 | ALK (0.66) | ALKKDRFLT3FLT4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434774-A1 | 3-(4-SUBSTITUTED HETEROCYCLYL)-PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2004-07-07 | — | — | EP | disclosed |
| US-6642232-B2 | Antitumor agents | SUGEN, INC. | 2003-11-04 | — | — | US | disclosed |
| US-20030130235-A1 | 3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors | SUGEN, INC. | 2003-07-10 | — | — | US | disclosed |
| WO-2003031438-A1 | 3-[4-(SUBSTITUTED HETEROCYCLYL)-PYRROL-2-YLMETHYLIDENE]-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2003-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130235-A1 | 3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors | PDGFRB, PDGFRA, KDR | ALK 62/4885KDR 3/4885FLT3 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.