Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.46 |
| ▸ | TUBB | P07437 | 2/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3280594 | 0.82 | TP53 (0.52) | HSD17B10ALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL3283082 | 0.81 | SMN1; SMN2 (0.43) | HSD17B10ALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL3276888 | 0.75 | S1PR1 (0.49) | HSD17B10ALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL13384700 | 0.75 | NPC1 (0.51) | ALDH1A1TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3276801 | 0.74 | S1PR1 (0.49) | HSD17B10ALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL4443234 | 0.74 | S1PR1 (0.49) | HSD17B10ALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL13384705 | 0.73 | RAB9A (0.54) | HSD17B10ALDH1A1KDM4ETP53SMN1; SMN2 | |
| SCHEMBL3277735 | 0.73 | S1PR1 (0.53) | RAB9ANPC1S1PR1 | |
| SCHEMBL1425008 | 0.73 | S1PR1 (0.52) | HSD17B10ALDH1A1TP53SMN1; SMN2RAB9A | |
| SCHEMBL3276290 | 0.72 | S1PR1 (0.41) | HSD17B10TP53SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125797-B1 | AMINO- PYRIDINE DERIVATIVES AS S1P1 /EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2014-01-15 | — | — | EP | disclosed |
| US-8592460-B2 | Amino-pyridine derivatives as S1P1 /EDG1 receptor agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-11-26 | — | — | US | disclosed |
| CN-101627034-B | amino-pyridine derivatives as S1P1/EDG1 receptor agonists | ACTELION PHARMACEUTICALS LTD | 2013-05-15 | — | — | CN | disclosed |
| US-20100087417-A1 | AMINO-PYRIDINE DERIVATIVES AS S1P1 /EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-04-08 | — | — | US | disclosed |
| CN-101627034-A | Amino-pyridine derivatives as S1P1/EDG1 receptor agonists | ACTELION PHARMACEUTICALS LTD | 2010-01-13 | — | — | CN | disclosed |
| EP-2125797-A1 | AMINO- PYRIDINE DERIVATIVES AS S1P1 /EDG1 RECEPTOR AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008114157-A1 | AMINO- PYRIDINE DERIVATIVES AS S1P1 /EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087417-A1 | AMINO-PYRIDINE DERIVATIVES AS S1P1 /EDG1 RECEPTOR AGONISTS | S1PR1, S1PR3, S1PR4 | HSD17B10 4434/4885ALDH1A1 2789/4885KDM4E 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.