⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1651477 | 0.67 | — | — | |
| SCHEMBL31611874 | 0.67 | — | — | |
| SCHEMBL8833247 | 0.66 | — | — | |
| SCHEMBL6726425 | 0.66 | — | — | |
| SCHEMBL3488485 | 0.64 | — | — | |
| SCHEMBL8135056 | 0.64 | — | — | |
| SCHEMBL30926061 | 0.64 | MEN1 (0.40) | — | |
| SCHEMBL30979820 | 0.63 | — | — | |
| SCHEMBL2512897 | 0.63 | — | — | |
| SCHEMBL4066683 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569317-B2 | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives | NOVARTIS AG (CH) | 2013-10-29 | — | — | US | disclosed |
| US-7696216-B2 | Aryl-quinazoline/aryl-2-amino-phenyl methanone derivatives | NOVARTIS AG (CH) | 2010-04-13 | — | — | US | disclosed |
| US-20100063075-A1 | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives | ALTMANN EVA | 2010-03-11 | — | — | US | disclosed |
| CN-101445486-A | Derivatives of aryl-quinazoline/aryl-2-amino-phenyl methanone which promote the release of parathyroid hormone | NOVARTIS PHARMA AG (CH) | 2009-06-03 | — | — | CN | disclosed |
| EP-1585521-B8 | DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE | NOVARTIS AG (CH) | 2009-03-25 | — | — | EP | disclosed |
| EP-1585521-B1 | DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE | NOVARTIS AG (CH) | 2008-06-18 | — | — | EP | disclosed |
| EP-1844780-A2 | Derivatives of aryl-quinazoline/aryl-2-amino-phenyl methanone which promote the release of parathyroid hormone | Novartis Pharma AG (CH) | 2007-10-17 | — | — | EP | disclosed |
| US-20060079685-A1 | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives | NOVARTIS AG (CH) | 2006-04-13 | — | — | US | disclosed |
| CN-1732002-A | Aryl-quinazoline/aryl-2-amino-phenyl methanone derivatives for promoting parathyroid hormone release | NOVARTIS AG (CH) | 2006-02-08 | — | — | CN | disclosed |
| EP-1585521-A2 | DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE | Novartis AG (CH) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004056365-A2 | DERIVATIVES OF ARYL-QUINAZOLINE/ARYL-2AMINO-PHENYL METHANONE WHICH PROMOTE THE RELEASE OF PARATHYROID HORMONE | NOVARTIS AG (CH) | 2004-07-08 | — | — | WO | disclosed |