Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 6/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3276059 | 0.85 | CYSLTR1 (0.66) | PDE10ACYSLTR1GPBAR1CYP1A2FFAR1 | |
| SCHEMBL3270051 | 0.83 | GPBAR1 (0.66) | ALOX5PDE10ACYSLTR1GPBAR1FFAR1 | |
| SCHEMBL3278184 | 0.82 | NOX1 (0.59) | ALOX5 | |
| SCHEMBL3270105 | 0.82 | ALOX5 (0.48) | ALOX5PDE10ACYSLTR1GPBAR1FFAR1 | |
| SCHEMBL3272995 | 0.81 | CYSLTR1 (0.57) | ALOX5PDE10ACYSLTR1GPBAR1FFAR1 | |
| SCHEMBL3271686 | 0.81 | PDE10A (0.65) | ALOX5PDE10ACYSLTR1GPBAR1FFAR1 | |
| SCHEMBL3275392 | 0.80 | PDE10A (0.48) | ALOX5PDE10ACYSLTR1GPBAR1 | |
| SCHEMBL27716189 | 0.79 | PDE10A (0.49) | ALOX5PDE10ACYSLTR1GPBAR1CYP1A2 | |
| SCHEMBL3275859 | 0.76 | ALOX5 (0.55) | ALOX5PDE10ACYSLTR1GPBAR1ALOX5AP | |
| SCHEMBL4150300 | 0.75 | GPBAR1 (0.65) | ALOX5PDE10ACYSLTR1GPBAR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825254-B2 | Heteroaromatic quinoline compounds | PFIZER INC. (US) | 2010-11-02 | — | — | US | disclosed |
| EP-1841757-B1 | HETEROAROMATIC QUINOLINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | PFIZER PROD INC (US) | 2010-06-30 | — | — | EP | disclosed |
| US-7429665-B2 | Heteroaromatic quinoline compounds | PFIZER INC (US) | 2008-09-30 | — | — | US | disclosed |
| US-20080214607-A1 | HETEROAROMATIC QUINOLINE COMPOUNDS | PFIZER INC | 2008-09-04 | — | — | US | disclosed |
| EP-1841757-A2 | HETEROAROMATIC QUINOLINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | Pfizer Products Incorporated (US) | 2007-10-10 | — | — | EP | disclosed |
| US-20060154931-A1 | Heteroaromatic quinoline compounds | PFIZER INC | 2006-07-13 | — | — | US | disclosed |
| WO-2006072828-A2 | HETEROAROMATIC QUINOLINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154931-A1 | Heteroaromatic quinoline compounds | PDE12, PDE7A, PDE4A | ALOX5 705/4885PDE10A 8/4885CYSLTR1 2546/4885 |
| US-20080214607-A1 | HETEROAROMATIC QUINOLINE COMPOUNDS | PDE12, PDE7A, PDE4A | ALOX5 705/4885PDE10A 8/4885CYSLTR1 2546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.