Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 0.72 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.68 |
| ▸ | DRD2 | P14416 | 2/20 | 0.97 |
| ▸ | DRD4 | P21917 | 2/20 | 0.97 |
| ▸ | MEN1 | O00255 | 1/20 | 0.97 |
| ▸ | ABL1 | P00519 | 1/20 | 0.97 |
| ▸ | ALPL | P05186 | 1/20 | 0.97 |
| ▸ | GAA | P10253 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.97 |
| ▸ | KDM1A | O60341 | 1/20 | 0.77 |
| ▸ | TBXA2R | P21731 | 7/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221137 | 0.99 | DRD2 (1.00) | DRD2DRD4MEN1ABL1ALPL | |
| SCHEMBL29375567 | 0.99 | DRD2 (1.00) | DRD2DRD4MEN1ABL1ALPL | |
| SCHEMBL29373547 | 0.99 | DRD2 (1.00) | DRD2DRD4MEN1ABL1ALPL | |
| SCHEMBL16602137 | 0.99 | DRD2 (1.00) | DRD2DRD4MEN1ABL1ALPL | |
| (+)-Higenamine SCHEMBL5898932 | 0.89 | DRD2 (0.97) | DRD2DRD4MEN1ABL1ALPL | |
| (-)-Higenamine SCHEMBL5898916 | 0.89 | DRD2 (0.97) | DRD2DRD4MEN1ABL1ALPL | |
| SCHEMBL13686544 | 0.88 | DRD2 (0.80) | DRD2DRD4MEN1ABL1ALPL | |
| SCHEMBL16281797 | 0.88 | DRD2 (0.80) | DRD2DRD4MEN1ABL1ALPL | |
| (-)-Higenamine SCHEMBL5898911 | 0.87 | DRD2 (1.00) | DRD2DRD4MEN1ABL1ALPL | |
| (+)-Higenamine SCHEMBL5898913 | 0.87 | DRD2 (1.00) | DRD2DRD4MEN1ABL1ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664262-A2 | THE USE OF LABIATAE HERB PREPARATIONS FOR FOAM ENCHANCEMENT OF BEVERAGES | Kalamazoo Holdings, Inc. (US) | 2006-06-07 | — | — | EP | claimed |
| US-20050106306-A1 | Use of Labiatae herb preparations for foam enhancement of malt beverages | KALAMAZOO HOLDINGS, INC. | 2005-05-19 | — | — | US | claimed |
| WO-2005028610-A2 | THE USE OF LABIATAE HERB PREPARATIONS FOR FOAM ENCHANCEMENT OF BEVERAGES | KALAMAZOO HOLDINGS, INC. (US) | 2005-03-31 | — | — | WO | claimed |
| US-6562836-B1 | Islet amyloid polypeptide (IAPP) is known to be capable of forming fibrils which are deposited in the pancreas of patients wtih type II diabetes | QUEEN'S UNIVERSITY OF KINGSTON (CA) | 2003-05-13 | — | — | US | claimed |
| EP-0667245-A1 | Recording sheets containing alcohols and saccharides | XEROX CORPORATION (US) | 1995-08-16 | — | — | EP | claimed |
| WO-2014104408-A1 | BEER FLAVORED CARBONATED BEVERAGE | KAO CORPORATION (JP) | 2014-07-03 | — | — | WO | disclosed |
| EP-1664262-B1 | THE USE OF LABIATAE HERB PREPARATIONS FOR FOAM ENCHANCEMENT OF BEVERAGES | KALAMAZOO HOLDINGS INC (US) | 2010-06-30 | — | — | EP | disclosed |
| US-7629400-B2 | Image making medium | HYMAN SYDNEY | 2009-12-08 | — | — | US | disclosed |
| WO-2008021210-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | COMBINATORX, INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | CHDI, INCORPORATED | 2008-02-21 | — | — | US | disclosed |
| EP-1664262-A2 | THE USE OF LABIATAE HERB PREPARATIONS FOR FOAM ENCHANCEMENT OF BEVERAGES | Kalamazoo Holdings, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20050106306-A1 | Use of Labiatae herb preparations for foam enhancement of malt beverages | KALAMAZOO HOLDINGS, INC. | 2005-05-19 | — | — | US | disclosed |
| WO-2005028610-A2 | THE USE OF LABIATAE HERB PREPARATIONS FOR FOAM ENCHANCEMENT OF BEVERAGES | KALAMAZOO HOLDINGS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
| US-20030035917-A1 | Image making medium | HYMAN SYDNEY (US) | 2003-02-20 | — | — | US | disclosed |
| EP-0667245-A1 | Recording sheets containing alcohols and saccharides | XEROX CORPORATION (US) | 1995-08-16 | — | — | EP | disclosed |
| US-4279914-A | 1-GLAUCINE OR TETRAHYDROXYAPORPHINE, ANTICOAGULANTS | HERMANN GOTTFRIED SCHNABEL FA. (DE) | 1981-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080044390-A1 | Methods and compositions for the treatment of neurodegenerative disorders | HTT, SNCA, NLN | ADRB2 4208/4885ADRB1 3918/4885DRD2 3226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.