Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13161136 | 1.00 | REN (0.42) | RENALDH1A1CYP3A4CYP2D6THRB | |
| SCHEMBL3277251 | 0.95 | REN (0.45) | RENTSHR | |
| SCHEMBL8435065 | 0.95 | REN (0.43) | RENALDH1A1CYP3A4CYP2D6THRB | |
| SCHEMBL13161210 | 0.95 | REN (0.45) | RENTSHR | |
| SCHEMBL3267579 | 0.95 | REN (0.43) | RENALDH1A1CYP3A4CYP2D6THRB | |
| SCHEMBL8428938 | 0.94 | REN (0.48) | RENTSHRAXLMERTK | |
| SCHEMBL4583046 | 0.94 | REN (0.42) | RENAXLMERTK | |
| SCHEMBL8430160 | 0.94 | REN (0.49) | REN | |
| SCHEMBL8427519 | 0.94 | REN (0.42) | RENAXLMERTK | |
| SCHEMBL3272419 | 0.94 | REN (0.48) | RENTSHRAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863802-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2010-06-16 | — | — | EP | disclosed |
| EP-1987834-A2 | Substituted piperidines as therapeutic compounds | Speedel Experimenta AG (CH) | 2008-11-05 | — | — | EP | disclosed |