Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | F12 | P00748 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 6/20 | 0.42 |
| ▸ | CA2 | P00918 | 6/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL169719 | 0.90 | PLAU (0.52) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL29482553 | 0.90 | PLAU (0.52) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL29277533 | 0.76 | CYP2A6 (0.55) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL10401348 | 0.74 | CYP2A6 (0.59) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL329993 | 0.74 | CYP2A6 (0.53) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL4729572 | 0.73 | PLAU (0.44) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL329994 | 0.73 | CYP2A6 (0.52) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL5610261 | 0.73 | CYP2A6 (0.52) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL29797287 | 0.73 | CYP2A6 (0.52) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL1052021 | 0.73 | CYP2A6 (0.52) | PLAUCYP2A6F12NCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696221-B2 | Thienoisoquinoline-phenylsulfonamides and their use as ER-NFκB inhibitors | WYETH LLC (US) | 2010-04-13 | — | — | US | disclosed |
| US-20060154875-A1 | Thienoisoquinoline-phenylsulfonamides and their use as ER-NFkappaB inhibitors | WYETH (US) | 2006-07-13 | — | — | US | disclosed |
| WO-2006069182-A2 | THIENOISOQUINOLINE-PHENYLSULFONAMIDES AND THEIR USE AS ER-NFkB INHIBITORS | WYETH (US) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060154875-A1 | Thienoisoquinoline-phenylsulfonamides and their use as ER-NFkappaB inhibitors | NFKBIA, IKBKB, IKBKE | PLAU 4571/4885CYP2A6 1413/4885F12 3635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.