Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250429 | 0.95 | PLK4 (0.49) | PLK4AURKANUAK1EGFRERBB2 | |
| Hemibastadinol 1 SCHEMBL3255108 | 0.93 | PLK4 (0.49) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL3256869 | 0.84 | HDAC1 (0.46) | CA1CA2CA9CA12MAPT | |
| SCHEMBL27944339 | 0.76 | PLK4 (0.55) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL3247417 | 0.76 | MEN1 (0.49) | CA1CA2CA9CA12MAPT | |
| SCHEMBL3263409 | 0.75 | MEN1 (0.46) | CA1CA2CA9CA12MAPT | |
| SCHEMBL30983754 | 0.75 | KDM4E (0.73) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL29210589 | 0.75 | KDM4E (0.73) | PLK4AURKANUAK1EGFRERBB2 | |
| Hemibastadin 2 SCHEMBL6803113 | 0.73 | PLK4 (0.89) | PLK4AURKANUAK1EGFRERBB2 | |
| SCHEMBL3522487 | 0.71 | KDM6B (0.72) | EGFRHSD17B10KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700522-B2 | α-Oxygenated or α-thiolated carboxylic acid phenethylamide derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2010-04-20 | — | — | US | claimed |
| US-6734211-B1 | FOR STIMULATING NERVE CELL GROWTH IN A SUBJECT COMPRISING ADMINISTERING TO THE SUBJECT A BASTADIN COMPOUND OR ITS ANALOGS | OREGON HEALTH & SCIENCES UNIVERSITY | 2004-05-11 | — | — | US | disclosed |