Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 9/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPY2R | P49146 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3278306 | 1.00 | GAA (0.50) | GAANPY5RAOC3KDM4EALDH1A1 | |
| SCHEMBL3278311 | 1.00 | GAA (0.50) | GAANPY5RAOC3KDM4EALDH1A1 | |
| SCHEMBL31106918 | 0.80 | GAA (0.51) | GAANPY5RAOC3KDM4EALDH1A1 | |
| SCHEMBL14338232 | 0.74 | GAA (0.64) | GAANPY5RAOC3KDM4EALDH1A1 | |
| SCHEMBL14197120 | 0.74 | GAA (0.64) | GAANPY5RAOC3KDM4EALDH1A1 | |
| SCHEMBL14368075 | 0.74 | GAA (0.64) | GAANPY5RAOC3KDM4EALDH1A1 | |
| SCHEMBL14338233 | 0.74 | GAA (0.64) | GAANPY5RAOC3KDM4EALDH1A1 | |
| SCHEMBL3310407 | 0.73 | GAA (0.43) | GAANPY5RAOC3KDM4EALDH1A1 | |
| SCHEMBL3310414 | 0.73 | GAA (0.43) | GAANPY5RAOC3KDM4EALDH1A1 | |
| SCHEMBL3310411 | 0.73 | GAA (0.43) | GAANPY5RAOC3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152171-A1 | CGRP Antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-06-17 | — | — | US | disclosed |
| US-7700589-B2 | CGRP antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2010-04-20 | — | — | US | disclosed |
| US-20070244099-A1 | CGRP Antagonists | RUDOLF KLAUS | 2007-10-18 | — | — | US | disclosed |
| US-20040132716-A1 | CGRP antagonists | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244099-A1 | CGRP Antagonists | CALCRL, OPRL1, CALCA | GAA 4211/4885NPY5R 44/4885AOC3 1028/4885 |
| US-20100152171-A1 | CGRP Antagonists | CALCRL, OPRL1, CALCA | GAA 4211/4885NPY5R 44/4885AOC3 1028/4885 |
| US-20040132716-A1 | CGRP antagonists | OPRL1, HTR1D, CALCA | GAA 4270/4885NPY5R 43/4885AOC3 1546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.