⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781982 | 0.76 | PSEN1 (0.31) | — | |
| SCHEMBL23975737 | 0.75 | BLM (0.31) | — | |
| SCHEMBL14170465 | 0.73 | CCR2 (0.35) | — | |
| SCHEMBL4012275 | 0.66 | — | — | |
| SCHEMBL50584 | 0.66 | — | — | |
| SCHEMBL50585 | 0.66 | — | — | |
| SCHEMBL29646367 | 0.66 | — | — | |
| SCHEMBL20588809 | 0.66 | — | — | |
| SCHEMBL13483622 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL2114066 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828119-B2 | Deprotecting a hydroxide or amine; obtain sample, incubate with enzyme, remoe protecting group, recover amine | BRISTOL MYERS SQUIBB COMPANY | 2004-12-07 | — | — | US | claimed |
| EP-1348025-A2 | ENZYMATIC DEPROTECTION OF AMINES AND HYDROXIDES | Bristol-Myers Squibb Company (US) | 2003-10-01 | — | — | EP | claimed |
| US-20020123110-A1 | Enzymatic deprotection of amines and hydroxides | BRISTOL-MYERS SQUIBB COMPANY | 2002-09-05 | — | — | US | claimed |
| WO-2002053724-A2 | ENZYMATIC DEPROTECTION OF AMINES AND HYDROXIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-07-11 | — | — | WO | claimed |
| US-7696328-B2 | N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-13 | — | — | US | disclosed |
| US-20090104670-A1 | N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor | BRISTOL-MYERS SQUIBB COMPANY | 2009-04-23 | — | — | US | disclosed |
| US-7416876-B2 | N-carbobenzyloxy (N-CBZ)-deprotecting enzyme | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2008-08-26 | — | — | US | disclosed |
| US-7390801-B2 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds | ATHENA NEUROSCIENCES, INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-7390801-B2 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds | ATHENA NEUROSCIENCES, INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-20070203108-A1 | Alzheimer's disease; 5-{N'-(4-thianaphthenacetyl)-L-alaninyl}-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one | THORSETT EUGENE D | 2007-08-30 | — | — | US | disclosed |
| US-20070203108-A1 | Alzheimer's disease; 5-{N'-(4-thianaphthenacetyl)-L-alaninyl}-amino-7-methyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one | THORSETT EUGENE D | 2007-08-30 | — | — | US | disclosed |
| US-20060275878-A1 | N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor | BRISTOL-MYERS SQUIBB COMPANY | 2006-12-07 | — | — | US | disclosed |
| US-7119188-B2 | N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060149047-A1 | N-CARBOBENZYLOXY (N-CBZ)-DEPROTECTING ENZYME AND USES THEREFOR | BRISTOL-MYERS SQUIBB COMPANY | 2006-07-06 | — | — | US | disclosed |
| US-6828119-B2 | Deprotecting a hydroxide or amine; obtain sample, incubate with enzyme, remoe protecting group, recover amine | BRISTOL MYERS SQUIBB COMPANY | 2004-12-07 | — | — | US | disclosed |
| EP-1348025-A2 | ENZYMATIC DEPROTECTION OF AMINES AND HYDROXIDES | Bristol-Myers Squibb Company (US) | 2003-10-01 | — | — | EP | disclosed |
| US-20020123110-A1 | Enzymatic deprotection of amines and hydroxides | BRISTOL-MYERS SQUIBB COMPANY | 2002-09-05 | — | — | US | disclosed |
| WO-2002053724-A2 | ENZYMATIC DEPROTECTION OF AMINES AND HYDROXIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-07-11 | — | — | WO | disclosed |