Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA7 | P43166 | 3/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31265674 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2132489 | 0.86 | KMT2A (0.60) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1939799 | 0.79 | KMT2A (0.58) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1939642 | 0.79 | NPSR1 (0.44) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL14294953 | 0.78 | KMT2A (0.53) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16875050 | 0.76 | KMT2A (0.51) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15410879 | 0.75 | ALDH1A1 (0.66) | ALDH1A1KMT2AKDM4EMEN1HTT | |
| SCHEMBL11225658 | 0.74 | HSP90AB1 (0.40) | KMT2ACYP1A2CYP2C9CYP2C19CA1 | |
| SCHEMBL13729450 | 0.74 | ALDH1A1 (0.59) | ALDH1A1KMT2AKDM4EMEN1HTT | |
| SCHEMBL11191903 | 0.74 | HSP90AB1 (0.40) | KMT2ACYP1A2CYP2C9CYP2C19CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872507-A1 | AZAINDOLE DERIVATIVES WHICH ACT AS PI3K INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2015-05-20 | — | — | EP | disclosed |
| US-20140343033-A1 | AZAINDOLE DERIVATIVES | Takeda Califomia, Inc. (US) | 2014-11-20 | — | — | US | disclosed |
| US-8835420-B2 | Azaindole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-09-16 | — | — | US | disclosed |
| US-20140018344-A1 | AZAINDOLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-01-16 | — | — | US | disclosed |
| WO-2014011568-A1 | AZAINDOLE DERIVATIVES WHICH ACT AS PI3K INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-01-16 | — | — | WO | disclosed |
| US-7700768-B2 | Compounds | GLAXOSMITHKLINE LLC (US) | 2010-04-20 | — | — | US | disclosed |
| US-7629462-B2 | Tetrasubstituted pyrimidine compounds as chemical intermediates | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-08 | — | — | US | disclosed |
| US-20090048442-A1 | Novel compounds | SMITHKLINE BEECHAM CORPORATION | 2009-02-19 | — | — | US | disclosed |
| US-20070238743-A1 | 1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION | 2007-10-11 | — | — | US | disclosed |
| EP-1842851-A2 | Novel compounds | Smithkline Beecham Corporation (US) | 2007-10-10 | — | — | EP | disclosed |
| US-20070167467-A1 | 1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION | 2007-07-19 | — | — | US | disclosed |
| US-7235551-B2 | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-26 | — | — | US | disclosed |
| EP-1265900-B1 | 1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO 4,5-D|PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES | SMITHKLINE BEECHAM CORP (US) | 2007-05-16 | — | — | EP | disclosed |
| US-20030100756-A1 | 1,5- disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases | GLAXOSMITHKLINE LLC | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100756-A1 | 1,5- disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases | MAPKAPK2, MAPK4, MAP4K2 | ALDH1A1 3713/4885KMT2A 3768/4885CYP1A2 4476/4885 |
| US-20070167467-A1 | 1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES | MAPKAPK2, CREBBP, CNBP | ALDH1A1 3443/4885KMT2A 3558/4885CYP1A2 4435/4885 |
| US-20140343033-A1 | AZAINDOLE DERIVATIVES | PIK3R5, PIK3R1, PIK3R2 | ALDH1A1 1597/4885KMT2A 2404/4885CYP1A2 600/4885 |
| US-20070238743-A1 | 1,5-DISUBSTITUTED-3,4-DIHYDRO-1H-PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CSBP/P38 KINASE MEDIATED DISEASES | MAPKAPK2, CREBBP, CNBP | ALDH1A1 3443/4885KMT2A 3558/4885CYP1A2 4435/4885 |
| US-20090048442-A1 | Novel compounds | CREBBP, MAPKAPK2, CNBP | ALDH1A1 3936/4885KMT2A 3486/4885CYP1A2 4644/4885 |
| US-20140018344-A1 | AZAINDOLE DERIVATIVES | PIK3R5, PIK3R1, PIK3R2 | ALDH1A1 1597/4885KMT2A 2404/4885CYP1A2 600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.