Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.41 |
| ▸ | FLT1 | P17948 | 10/20 | 0.41 |
| ▸ | FLT3 | P36888 | 8/20 | 0.41 |
| ▸ | CSF1R | P07333 | 8/20 | 0.41 |
| ▸ | FLT4 | P35916 | 8/20 | 0.41 |
| ▸ | LCK | P06239 | 7/20 | 0.41 |
| ▸ | KIT | P10721 | 7/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.41 |
| ▸ | AURKA | O14965 | 5/20 | 0.41 |
| ▸ | LYN | P07948 | 5/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.41 |
| ▸ | STK3 | Q13188 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 4/20 | 0.41 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.41 |
| ▸ | GSK3A | P49840 | 4/20 | 0.41 |
| ▸ | FYN | P06241 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328095 | 0.91 | KDR (0.42) | KDRFLT1FLT3CSF1RFLT4 | |
| SCHEMBL275484 | 0.88 | KDR (0.53) | KDRFLT1FLT3CSF1RFLT4 | |
| SCHEMBL10273834 | 0.78 | KDR (0.55) | KDRFLT1FLT3CSF1RFLT4 | |
| SCHEMBL277119 | 0.78 | KDR (0.55) | KDRFLT1FLT3CSF1RFLT4 | |
| SCHEMBL327891 | 0.78 | KDR (0.49) | KDRFLT1FLT3CSF1RFLT4 | |
| SCHEMBL275144 | 0.77 | KDR (0.50) | KDRFLT1FLT3CSF1RFLT4 | |
| SCHEMBL10273031 | 0.76 | KDR (0.54) | KDRFLT1FLT3CSF1RFLT4 | |
| SCHEMBL276439 | 0.74 | KDR (0.51) | KDRFLT1FLT3CSF1RFLT4 | |
| SCHEMBL327888 | 0.74 | FLT3 (0.60) | KDRFLT1FLT3CSF1RFLT4 | |
| SCHEMBL16015585 | 0.74 | KDR (0.50) | KDRFLT1FLT3CSF1RFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133995-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2012-03-13 | — | — | US | disclosed |
| US-20090281079-A1 | Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated With Angiogenesis | BAYER HEALTHCARE LLV (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281079-A1 | Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated With Angiogenesis | CDK4, FLT4, CDKL4 | KDR 27/4885FLT1 5/4885FLT3 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.