Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281290 | 0.92 | SCN9A (0.50) | SCN9ATNKSTNKS2SLC6A5KMT2A | |
| SCHEMBL3330600 | 0.89 | SCN9A (0.43) | SCN9ATNKSTNKS2SLC6A5KMT2A | |
| SCHEMBL281086 | 0.85 | SCN9A (0.52) | SCN9ALMNASCN7ASCN5ASCN2A | |
| SCHEMBL281176 | 0.85 | NPC1 (0.52) | SCN9ASLC6A5KMT2ANPC1RAB9A | |
| SCHEMBL280900 | 0.84 | SCN9A (0.52) | SCN9ASLC6A5KMT2ANPC1RAB9A | |
| SCHEMBL280788 | 0.84 | SCN9A (0.52) | SCN9ASLC6A5NPC1RAB9AMAPT | |
| SCHEMBL281091 | 0.83 | NPC1 (0.56) | SCN9AKMT2ANPC1RAB9AMAPT | |
| SCHEMBL280818 | 0.82 | RAB9A (0.51) | SCN9ASLC6A5NPC1RAB9AMAPT | |
| SCHEMBL328305 | 0.81 | SCN9A (0.50) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL10289089 | 0.81 | NPC1 (0.49) | SCN9AKMT2ANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428515-A1 | Spiro-oxindole compounds and their uses as therapeutic agents | Xenon Pharmaceuticals Inc. (CA) | 2012-03-14 | — | — | EP | disclosed |
| EP-1888595-B1 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC (CA) | 2012-02-01 | — | — | EP | disclosed |