Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.47 |
| ▸ | EML4 | Q9HC35 | 11/20 | 0.47 |
| ▸ | RET | P07949 | 5/20 | 0.44 |
| ▸ | ROS1 | P08922 | 5/20 | 0.44 |
| ▸ | FLT3 | P36888 | 5/20 | 0.44 |
| ▸ | AXL | P30530 | 4/20 | 0.40 |
| ▸ | ETV6 | P41212 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10156548 | 0.82 | ALK (0.48) | ALKEML4RETROS1FLT3 | |
| SCHEMBL17340282 | 0.80 | ALK (0.46) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10156818 | 0.77 | ALK (0.70) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10156944 | 0.75 | ALK (0.60) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10157381 | 0.75 | ALK (0.60) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10126641 | 0.72 | EML4 (0.45) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10155933 | 0.72 | ALK (0.46) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10156483 | 0.69 | EML4 (0.42) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10158010 | 0.68 | ALK (0.71) | ALKEML4RETROS1FLT3 | |
| SCHEMBL10156754 | 0.68 | ALK (0.54) | ALKEML4RETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2012-03-14 | — | — | EP | disclosed |