Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280762 | 0.92 | SCN9A (0.42) | SCN9ABACE1SCN7ASCN5ASCN2A | |
| SCHEMBL10267012 | 0.90 | SCN9A (0.54) | SCN9ABACE1SCN7ASCN5ASCN2A | |
| SCHEMBL281917 | 0.87 | TP53 (0.39) | SCN9ABACE1TP53MAPTLMNA | |
| SCHEMBL2307297 | 0.85 | SCN9A (0.48) | SCN9ABACE1SCN7ASCN5ASCN2A | |
| SCHEMBL281722 | 0.83 | SCN9A (0.58) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL284065 | 0.81 | SCN9A (0.44) | SCN9ABACE1SCN7ASCN5ASCN2A | |
| SCHEMBL2306217 | 0.81 | SCN9A (0.55) | SCN9ABACE1SCN7ASCN5ASCN2A | |
| SCHEMBL281544 | 0.79 | SCN9A (0.45) | SCN9ABACE1KDM4EPKM | |
| SCHEMBL10258994 | 0.77 | GPR119 (0.39) | SCN9ABACE1MAPTUTS2R | |
| SCHEMBL282004 | 0.75 | SCN9A (0.59) | SCN9ASCN7ASCN5ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428515-A1 | Spiro-oxindole compounds and their uses as therapeutic agents | Xenon Pharmaceuticals Inc. (CA) | 2012-03-14 | — | — | EP | disclosed |