Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 11/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.44 |
| ▸ | EGFR | P00533 | 7/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | ROS1 | P08922 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10127994 | 0.92 | EGFR (0.45) | EML4ALKEGFRRETROS1 | |
| SCHEMBL10129721 | 0.86 | EML4 (0.62) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10127946 | 0.85 | EGFR (0.45) | EML4ALKEGFRRETROS1 | |
| SCHEMBL10128006 | 0.85 | EGFR (0.53) | EML4ALKEGFRRETROS1 | |
| SCHEMBL10129623 | 0.81 | EML4 (0.64) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10127956 | 0.80 | EML4 (0.45) | EML4ALKEGFRRETROS1 | |
| SCHEMBL10129724 | 0.80 | ALK (0.61) | EML4ALKRETROS1FLT3 | |
| SCHEMBL17340373 | 0.80 | ALK (0.61) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10127938 | 0.79 | EGFR (0.53) | EML4ALKEGFRRETROS1 | |
| SCHEMBL10129687 | 0.76 | EML4 (0.66) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | Astellas Pharma Inc. (JP) | 2012-03-14 | — | — | EP | disclosed |