Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3284135 | 1.00 | ADORA1 (0.53) | ADORA1ADORA2AADORA2BMAPK8MAPK9 | |
| SCHEMBL3290820 | 0.84 | ADORA1 (0.61) | ADORA1ADORA2AADORA2BMAPK8MAPK9 | |
| SCHEMBL3290826 | 0.84 | ADORA1 (0.61) | ADORA1ADORA2AADORA2BMAPK8MAPK9 | |
| Bicarbonate SCHEMBL3908301 | 0.79 | ADORA1 (0.69) | ADORA1ADORA2AADORA2BMAPK8CDK2 | |
| SCHEMBL5444084 | 0.74 | KDM4E (0.57) | KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5457077 | 0.74 | KDM4E (0.57) | KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5444080 | 0.74 | KDM4E (0.57) | KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6456531 | 0.74 | MCHR1 (0.59) | MAPK8MAPK9CDK1CDK4CCND1 | |
| SCHEMBL6456524 | 0.74 | MCHR1 (0.59) | MAPK8MAPK9CDK1CDK4CCND1 | |
| SCHEMBL3284106 | 0.74 | ADORA1 (0.46) | ADORA1ADORA2AADORA2BCDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713988-B2 | 4,5-diphenyl-pyrimidinylamino substituted carboxylic acids, method for the production and use thereof as medicaments | SANOFI-AVENTIS (FR) | 2010-05-11 | — | — | US | disclosed |
| US-20090149487-A1 | 4,5-DIPHENYL-PYRIMIDINYLAMINO SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | SANOFI-AVENTIS (FR) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149487-A1 | 4,5-DIPHENYL-PYRIMIDINYLAMINO SUBSTITUTED CARBOXYLIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | GPR119, DPP4, SLC5A1 | ADORA1 478/4885ADORA2A 950/4885ADORA2B 485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.