Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.87 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Elinogrel SCHEMBL31722301 | 0.93 | P2RY12 (1.00) | P2RY12CA12CA9MAPTLMNA | |
| Elinogrel SCHEMBL160663 | 0.93 | P2RY12 (1.00) | P2RY12CA12CA9MAPTLMNA | |
| Elinogrel SCHEMBL27718842 | 0.92 | P2RY12 (0.98) | P2RY12CA12CA9MAPTLMNA | |
| Potassium Ion SCHEMBL31054166 | 0.85 | P2RY12 (0.75) | P2RY12CA12CA9MAPTLMNA | |
| Potassium Ion SCHEMBL195283 | 0.85 | P2RY12 (0.75) | P2RY12CA12CA9MAPTLMNA | |
| SCHEMBL9887822 | 0.85 | P2RY12 (0.75) | P2RY12CA12CA9MAPTLMNA | |
| SCHEMBL9922648 | 0.85 | P2RY12 (0.85) | P2RY12CA12CA9MAPTLMNA | |
| SCHEMBL15494787 | 0.84 | P2RY12 (0.84) | P2RY12CA12CA9MAPTLMNA | |
| SCHEMBL682018 | 0.84 | P2RY12 (0.84) | P2RY12CA12CA9MAPTLMNA | |
| SCHEMBL9922634 | 0.83 | P2RY12 (0.82) | P2RY12CA12CA9MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428514-A1 | [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto | Portola Pharmaceuticals, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2008137753-A2 | INTRAVENOUS AND ORAL DOSING OF A DIRECT-ACTING AND REVERSIBLE P2Y12 INHIBITOR | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |