Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 5/20 | 0.32 |
| ▸ | HTT | P42858 | 4/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | HTR3A | P46098 | 2/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL195283 | 1.00 | P2RY12 (0.75) | P2RY12LMNAKMT2AALDH1A1KDM4E | |
| Elinogrel SCHEMBL160663 | 0.86 | P2RY12 (1.00) | P2RY12LMNAKMT2AALDH1A1KDM4E | |
| Elinogrel SCHEMBL31722301 | 0.86 | P2RY12 (1.00) | P2RY12LMNAKMT2AALDH1A1KDM4E | |
| Elinogrel SCHEMBL27718842 | 0.85 | P2RY12 (0.98) | P2RY12LMNAKMT2AALDH1A1KDM4E | |
| SCHEMBL328669 | 0.85 | P2RY12 (0.87) | P2RY12LMNAKMT2AALDH1A1KDM4E | |
| SCHEMBL9887822 | 0.84 | P2RY12 (0.75) | P2RY12LMNAKMT2AALDH1A1KDM4E | |
| SCHEMBL20999566 | 0.79 | P2RY12 (0.67) | P2RY12LMNAKMT2AALDH1A1KDM4E | |
| SCHEMBL9281504 | 0.79 | P2RY12 (0.81) | P2RY12LMNAKMT2ATP53MAPT | |
| SCHEMBL156865 | 0.79 | P2RY12 (0.67) | P2RY12LMNAKMT2AALDH1A1KDM4E | |
| SCHEMBL20998977 | 0.78 | P2RY12 (0.71) | P2RY12LMNAKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260097102-A1 | Treatment Of Respiratory Disorders With Arachidonate 15-Lipoxygenase (ALOX15) Inhibitors | REGENERON PHARMA (US) | 2026-04-09 | — | — | US | disclosed |
| US-12472241-B2 | Treatment of respiratory disorders with arachidonate 15-lipoxygenase (ALOX15) inhibitors | REGENERON PHARMACEUTICALS, INC. (US) | 2025-11-18 | — | — | US | disclosed |
| US-20250340857-A1 | IgE PROTEASES AND USES THEREOF | SEISMIC THERAPEUTIC INC (US) | 2025-11-06 | — | — | US | disclosed |
| US-20250027068-A1 | PROTEASE VARIANTS AND USES THEREOF | SEISMIC THERAPEUTIC, INC. | 2025-01-23 | — | — | US | disclosed |
| US-12129499-B2 | Protease variants and uses thereof | SEISMIC THERAPEUTIC, INC. (US) | 2024-10-29 | — | — | US | disclosed |
| US-20240229002-A1 | PROTEASE VARIANTS AND USES THEREOF | SEISMIC THERAPEUTIC, INC. | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260097102-A1 | Treatment Of Respiratory Disorders With Arachidonate 15-Lipoxygenase (ALOX15) Inhibitors | ALOX15, ALOX15B, ALOX5 | P2RY12 591/4885LMNA 1753/4885KMT2A 3989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.