Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 6/20 | 0.51 |
| ▸ | RBPJ | Q06330 | 5/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 14/20 | 0.40 |
| ▸ | MMP3 | P08254 | 14/20 | 0.40 |
| ▸ | MMP7 | P09237 | 13/20 | 0.40 |
| ▸ | MMP1 | P03956 | 11/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3295050 | 0.73 | NOTCH1 (0.47) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287597 | 0.71 | NOTCH1 (0.67) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3295109 | 0.70 | NOTCH1 (0.79) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL13904300 | 0.70 | NOTCH1 (0.79) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287317 | 0.69 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL8244069 | 0.69 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL5839093 | 0.69 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3293655 | 0.69 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287486 | 0.69 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287198 | 0.69 | NOTCH1 (0.83) | NOTCH1RBPJPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718795-B2 | Succinoylamino benzodiazepines as inhibitors of aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2010-05-18 | — | — | US | disclosed |
| US-20080207602-A1 | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207602-A1 | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BACE1, APP, GABRE | NOTCH1 539/4885RBPJ 2293/4885PSEN1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.