Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 10/20 | 0.80 |
| ▸ | NR0B2 | Q15466 | 3/20 | 0.80 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.77 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.77 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.77 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.73 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.73 |
| ▸ | RARB | P10826 | 4/20 | 0.62 |
| ▸ | PTPRCAP | Q14761 | 2/20 | 0.60 |
| ▸ | RARA | P10276 | 1/20 | 0.52 |
| ▸ | RARG | P13631 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3289761 | 1.00 | PTPN11 (0.80) | PTPN11NR0B2HDAC11HDAC7HDAC8 | |
| SCHEMBL29604865 | 0.89 | PTPN11 (1.00) | PTPN11NR0B2HDAC11HDAC7HDAC8 | |
| SCHEMBL1914215 | 0.89 | PTPN11 (1.00) | PTPN11NR0B2HDAC11HDAC7HDAC8 | |
| SCHEMBL1914213 | 0.89 | PTPN11 (1.00) | PTPN11NR0B2HDAC11HDAC7HDAC8 | |
| SCHEMBL12257833 | 0.88 | PTPN11 (0.83) | PTPN11NR0B2HDAC11HDAC7HDAC8 | |
| SCHEMBL3295460 | 0.87 | HDAC2 (1.00) | PTPN11NR0B2HDAC11HDAC7HDAC8 | |
| SCHEMBL3295457 | 0.87 | HDAC2 (1.00) | PTPN11NR0B2HDAC11HDAC7HDAC8 | |
| SCHEMBL2391090 | 0.83 | PTPN11 (0.74) | PTPN11NR0B2HDAC11HDAC7HDAC8 | |
| SCHEMBL13310490 | 0.80 | HDAC8 (0.53) | PTPN11NR0B2HDAC11HDAC7HDAC8 | |
| SCHEMBL2407028 | 0.78 | PTPN11 (0.77) | PTPN11NR0B2HDAC11HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896399-B1 | BIPHENYL AND NAPHTHYL-PHENYL HYDROXAMIC ACID DERIVATIVES | SIGMA TAU IND FARMACEUTI (IT) | 2010-11-17 | — | — | EP | claimed |
| US-7728039-B2 | Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-06-01 | — | — | US | claimed |
| US-20080319082-A1 | Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-12-25 | — | — | US | claimed |
| EP-1896399-B1 | BIPHENYL AND NAPHTHYL-PHENYL HYDROXAMIC ACID DERIVATIVES | SIGMA TAU IND FARMACEUTI (IT) | 2010-11-17 | — | — | EP | disclosed |
| US-7728039-B2 | Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-06-01 | — | — | US | disclosed |
| US-7728039-B2 | Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-06-01 | — | — | US | disclosed |
| US-20080319082-A1 | Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-12-25 | — | — | US | disclosed |
| US-20080319082-A1 | Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-12-25 | — | — | US | disclosed |
| EP-1896399-A1 | BIPHENYL AND NAPHTHYL-PHENYL HYDROXAMIC ACID DERIVATIVES | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007000383-A1 | BIPHENYL AND NAPHTHYL-PHENYL HYDROXAMIC ACID DERIVATIVES | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319082-A1 | Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives | VHL, ARNT, AHR | PTPN11 2111/4885NR0B2 97/4885HDAC11 104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.