Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4329166 | 0.89 | TP53 (0.47) | TP53YAP1TEAD4MAPTSMN1; SMN2 | |
| SCHEMBL841382 | 0.89 | TP53 (0.47) | TP53YAP1TEAD4MAPTSMN1; SMN2 | |
| SCHEMBL1445825 | 0.86 | TP53 (0.43) | TP53YAP1TEAD4MAPTSMN1; SMN2 | |
| SCHEMBL4324743 | 0.81 | TP53 (0.49) | TP53YAP1TEAD4MAPTSMN1; SMN2 | |
| SCHEMBL842349 | 0.81 | TP53 (0.49) | TP53YAP1TEAD4MAPTSMN1; SMN2 | |
| SCHEMBL18568173 | 0.78 | TP53 (0.43) | TP53YAP1TEAD4MAPTSMN1; SMN2 | |
| SCHEMBL10310669 | 0.78 | TP53 (0.43) | TP53YAP1TEAD4MAPTSMN1; SMN2 | |
| SCHEMBL19974931 | 0.78 | GPR88 (0.40) | MAPTSMN1; SMN2KMT2AMEN1GPR88 | |
| SCHEMBL842533 | 0.75 | TP53 (0.46) | TP53YAP1TEAD4MAPTSMN1; SMN2 | |
| SCHEMBL842534 | 0.75 | TP53 (0.46) | TP53YAP1TEAD4MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407448-A2 | Processes and intermediates for preparing steric compounds | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-18 | — | — | EP | disclosed |