⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13767272 | 0.83 | GSR (0.35) | — | |
| SCHEMBL27782220 | 0.83 | TSHR (0.41) | — | |
| SCHEMBL19257464 | 0.83 | TSHR (0.41) | — | |
| SCHEMBL9602430 | 0.82 | — | — | |
| SCHEMBL7793314 | 0.79 | — | — | |
| SCHEMBL997152 | 0.78 | — | — | |
| SCHEMBL11758672 | 0.78 | GABBR2 (0.33) | — | |
| SCHEMBL20889082 | 0.78 | — | — | |
| SCHEMBL13745480 | 0.78 | — | — | |
| SCHEMBL11516931 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063887-B1 | NEW SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF | UNIV MICHIGAN (US) | 2013-05-29 | — | — | EP | disclosed |
| US-8222288-B2 | Small molecule inhibitors of MDM2 and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-07-17 | — | — | US | disclosed |
| US-20100317661-A1 | SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-12-16 | — | — | US | disclosed |
| US-7737174-B2 | Indole inhibitors of MDM2 and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-06-15 | — | — | US | disclosed |
| EP-2063887-A2 | NEW SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF | The Regents of the University of Michigan (US) | 2009-06-03 | — | — | EP | disclosed |
| US-20080125430-A1 | NEW SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-05-29 | — | — | US | disclosed |
| WO-2008036168-A2 | NEW SMALL MOLECULE INHIBITORS OF MDM2 AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-03-27 | — | — | WO | disclosed |