Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.30 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499060 | 0.98 | GPR17 (0.31) | GPR17APEX1KDM4ECHRM1 | |
| SCHEMBL498445 | 0.97 | GPR17 (0.31) | GPR17APEX1KDM4ECHRM1 | |
| Hydrochloric Acid SCHEMBL3293373 | 0.97 | KDM4E (0.33) | GPR17APEX1KDM4ECHRM1 | |
| Hydrochloric Acid SCHEMBL3293368 | 0.96 | KDM4E (0.32) | GPR17APEX1KDM4ECHRM1 | |
| Hydrochloric Acid SCHEMBL3289280 | 0.96 | KDM4E (0.32) | GPR17APEX1KDM4ECHRM1 | |
| SCHEMBL10722190 | 0.88 | — | — | |
| SCHEMBL6410839 | 0.87 | GPR17 (0.33) | TBXAS1GPR17APEX1KDM4ECHRM1 | |
| SCHEMBL6416150 | 0.87 | CHRM1 (0.38) | GPR17APEX1KDM4ECHRM1 | |
| Hydrochloric Acid SCHEMBL3289386 | 0.84 | KDM4E (0.36) | GPR17APEX1KDM4ECHRM1 | |
| SCHEMBL11894595 | 0.81 | RAD52 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1798600-B1 | Use of a porhine agent for reducing the potential of ghosting in an imaging member | XEROX CORP (US) | 2012-10-10 | — | — | EP | claimed |
| US-7718334-B2 | Imaging member having porphine or porphine derivatives | XEROX CORPORATION (US) | 2010-05-18 | — | — | US | claimed |
| US-20070141490-A1 | Imaging member | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT | 2007-06-21 | — | — | US | claimed |
| EP-1798600-A1 | Imaging Member | Xerox Corporation (US) | 2007-06-20 | — | — | EP | claimed |
| EP-1798600-B1 | Use of a porhine agent for reducing the potential of ghosting in an imaging member | XEROX CORP (US) | 2012-10-10 | — | — | EP | disclosed |
| US-7527904-B2 | Imaging member | XEROX CORPORATION (US) | 2009-05-05 | — | — | US | disclosed |
| US-20070141490-A1 | Imaging member | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT | 2007-06-21 | — | — | US | disclosed |
| EP-1798600-A1 | Imaging Member | Xerox Corporation (US) | 2007-06-20 | — | — | EP | disclosed |