Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL3359645 | 1.00 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TSHR | |
| Acetic Acid SCHEMBL15285365 | 1.00 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TSHR | |
| Acetic Acid SCHEMBL15689783 | 1.00 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TSHR | |
| Acetic Acid SCHEMBL17373805 | 1.00 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TSHR | |
| Acetic Acid SCHEMBL15090782 | 1.00 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TSHR | |
| Acetic Acid SCHEMBL15689725 | 1.00 | FFAR3 (0.64) | FFAR3LCKFYNALDH1A1TSHR | |
| Acetic Acid SCHEMBL36929 | 1.00 | — | — | |
| Acetic Acid SCHEMBL15391985 | 0.96 | — | — | |
| Acetic Acid SCHEMBL8854356 | 0.96 | FFAR3 (0.58) | FFAR3LCKFYNALDH1A1TSHR | |
| Acetic Acid SCHEMBL21489111 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670989-B1 | POWDER COMPOSITION FOR PAPER MANUFACTURING | KAO CORP (JP) | 2010-11-24 | — | — | EP | disclosed |
| US-7740742-B2 | Powder composition for paper manufacturing | KAO CORPORATION (JP) | 2010-06-22 | — | — | US | disclosed |
| CN-100552132-C | Paper quality improver | KAO CORP (JP) | 2009-10-21 | — | — | CN | disclosed |
| US-7547376-B2 | Paper improver | KAO CORPORATION (JP) | 2009-06-16 | — | — | US | disclosed |
| US-20060137844-A1 | Powder composition for paper manufacturing | KAO CORPORATION (JP) | 2006-06-29 | — | — | US | disclosed |
| EP-1670989-A1 | POWDER COMPOSITION FOR PAPER MANUFACTURING | Kao Corporation (JP) | 2006-06-21 | — | — | EP | disclosed |
| US-20060102306-A1 | high-speed high-shear papermaking; bulk, strength, brightness, opacity; acrylamide and t-octyl acrylamide nonionic monomers; methylchloride salt of dimethylaminopropyl acrylamide or diethyl sulfate salt of dimethylaminoethyl methacrylate cationics; surfactant | KAO CORPORATION (JP) | 2006-05-18 | — | — | US | disclosed |
| CN-1668812-A | Paper improver | KAO CORP (JP) | 2005-09-14 | — | — | CN | disclosed |
| EP-1538260-A1 | PAPER IMPROVER | Kao Corporation (JP) | 2005-06-08 | — | — | EP | disclosed |
| WO-2005012636-A1 | POWDER COMPOSITION FOR PAPER MANUFACTURING | KAO CORPORATION (JP) | 2005-02-10 | — | — | WO | disclosed |