⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL881755 | 0.82 | — | — | |
| SCHEMBL31010424 | 0.69 | — | — | |
| SCHEMBL17198 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL1935427 | 0.67 | MAPK1 (0.95) | — | |
| SCHEMBL9989891 | 0.65 | MAPK1 (0.60) | — | |
| SCHEMBL881773 | 0.64 | — | — | |
| SCHEMBL1933107 | 0.63 | MAPK1 (0.56) | — | |
| SCHEMBL18207739 | 0.62 | — | — | |
| SCHEMBL2316870 | 0.61 | MAPK1 (0.55) | — | |
| SCHEMBL650714 | 0.61 | MAPK1 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022040604-A1 | USE OF DP1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF VIRAL RESPIRATORY TRACT INFECTIONS AND DYSREGULATED IMMUNE RESPONSE IN AGED AND AGING PATIENTS | BioAge Labs, Inc. (US) | 2022-02-24 | — | — | WO | disclosed |
| US-9440938-B2 | Sulfonamide derivative having PGD2 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2016-09-13 | — | — | US | disclosed |
| US-20150158833-A1 | SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY | SHIONOGI & CO (JP) | 2015-06-11 | — | — | US | disclosed |
| CN-101273013-B | Sulfonamide derivative having PGD2 receptor antagonistic activity | SHIONOGI & CO | 2013-06-12 | — | — | CN | disclosed |
| US-8329718-B2 | N-linked heterocyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-12-11 | — | — | US | disclosed |
| US-8153793-B2 | Sulfonamide derivative having PGD2 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2012-04-10 | — | — | US | disclosed |
| WO-2011120327-A9 | ANTI-TUMOR MEDICAMENT OF STRUCTURE OF DIARYLUREA OR THIOUREA KIND BASED ON INDAZOLE OR AZA-INDAZOLE | 济南海乐医药技术开发有限公司 (CN) | 2012-03-29 | — | — | WO | disclosed |
| EP-2407453-A1 | PGD2 receptor antagonist | Shionogi & Co., Ltd. (JP) | 2012-01-18 | — | — | EP | disclosed |
| EP-2407459-A1 | Synthetic intermediate in the production of a sulfonamide derivative having PGD2 receptor antagonistic activity | Shionogi & Co., Ltd. (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-8053450-B2 | P2Y1 Purinoreceptor; thromboembolic disorders; compounds are 2-((hetero)arylamino) benzimidazoles, benzoxazoles or benzothiazoles such as [2-(2-tert-butyl-phenoxy)-pyridin-3-yl]-(6-methyl-1H-benzoimidazol-2-yl)-amine | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-11-08 | — | — | US | disclosed |
| WO-2011120327-A1 | ANTI-TUMOR MEDICAMENT OF STRUCTURE OF DIARYLUREA OR THIOUREA KIND BASED ON INDAZOLE OR AZA-INDAZOLE | 济南海乐医药技术开发有限公司 (CN) | 2011-10-06 | — | — | WO | disclosed |
| US-20100197716-A1 | N-LINKED HETEROCYCLIC ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS | BRISTOL-MYERS SQUIBB COMPANY | 2010-08-05 | — | — | US | disclosed |
| US-7700620-B2 | C-linked cyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-20 | — | — | US | disclosed |
| EP-1939175-A1 | SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY | Shionogi&Co., Ltd. (JP) | 2008-07-02 | — | — | EP | disclosed |