Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | CLPP | Q16740 | 2/20 | 0.40 |
| ▸ | PRLHR | P49683 | 2/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3296928 | 0.93 | CLPP (0.43) | NAMPTCLPPPRLHRCACNA1H | |
| SCHEMBL3297401 | 0.92 | CLPP (0.41) | NAMPTCLPPPRLHR | |
| SCHEMBL3295357 | 0.92 | CACNA1H (0.43) | CLPPPRLHRCACNA1H | |
| SCHEMBL3300262 | 0.91 | CLPP (0.40) | NAMPTCLPPPRLHR | |
| SCHEMBL3303714 | 0.91 | CLPP (0.40) | CLPPPRLHR | |
| SCHEMBL3294275 | 0.90 | CLPP (0.39) | CLPP | |
| SCHEMBL3295196 | 0.89 | PRLHR (0.43) | NAMPTCLPPPRLHR | |
| SCHEMBL3297983 | 0.89 | NPC1 (0.42) | NAMPTPRLHR | |
| SCHEMBL3296703 | 0.89 | PRLHR (0.49) | CLPPPRLHRCACNA1H | |
| SCHEMBL3297276 | 0.88 | MAPK1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232282-B2 | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-31 | — | — | US | disclosed |
| US-20100093771-A1 | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2078719-A1 | COMPOUND HAVING BICYCLIC PYRIMIDINE STRUCTURE AND PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2009-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093771-A1 | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same | GART, MGAT2, MGAT1 | NAMPT 115/4885CLPP 4670/4885PRLHR 3093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.