Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRLHR | P49683 | 10/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3299790 | 0.93 | RECQL (0.46) | PRLHRRECQLALDH1A1MAPTPDE10A | |
| SCHEMBL3301167 | 0.92 | PRLHR (0.48) | PRLHRRECQLALDH1A1MAPTPDE10A | |
| SCHEMBL3299804 | 0.92 | LMNA (0.50) | PRLHRRECQLPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL3301087 | 0.92 | RECQL (0.47) | PRLHRRECQLALDH1A1MAPTPDE10A | |
| SCHEMBL17358374 | 0.91 | RECQL (0.48) | PRLHRRECQLALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3302520 | 0.91 | PRLHR (0.47) | PRLHRRECQLALDH1A1MAPTMGAT2 | |
| SCHEMBL3299059 | 0.90 | PRLHR (0.49) | PRLHRRECQLALDH1A1MAPTPDE10A | |
| SCHEMBL3297467 | 0.89 | PRLHR (0.45) | PRLHRRECQLALDH1A1MAPTMGAT2 | |
| SCHEMBL3297793 | 0.89 | PRLHR (0.50) | PRLHRMGAT2 | |
| SCHEMBL3299870 | 0.89 | CDK1 (0.52) | PRLHRRECQLALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016024598-A1 | NOVEL TETRAHYDRO PYRIDOPYRIMIDINONE DERIVATIVE | 味の素株式会社 | 2016-02-18 | — | — | WO | disclosed |
| US-20150368242-A1 | NOVEL TETRAHYDROPYRIDOPYRIMIDINONE DERIVATIVE | AJINOMOTO CO., INC. (JP) | 2015-12-24 | — | — | US | disclosed |
| WO-2014133134-A1 | NOVEL TETRAHYDROPYRIDOPYRIMIDINONE DERIVATIVE | 味の素株式会社 (JP) | 2014-09-04 | — | — | WO | disclosed |
| US-8232282-B2 | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-07-31 | — | — | US | disclosed |
| US-20100093771-A1 | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2078719-A1 | COMPOUND HAVING BICYCLIC PYRIMIDINE STRUCTURE AND PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2009-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093771-A1 | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same | GART, MGAT2, MGAT1 | PRLHR 3093/4885RECQL 1541/4885PRKAB2 2266/4885 |
| US-20150368242-A1 | NOVEL TETRAHYDROPYRIDOPYRIMIDINONE DERIVATIVE | MGAT2, MGAT1, MGAT3 | PRLHR 1904/4885RECQL 4237/4885PRKAB2 2603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.