Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loxoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 17/20 | 0.97 |
| ▸ | PTGS2 known ✓ | P35354 | 17/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.97 |
| ▸ | HTT | P42858 | 1/20 | 0.97 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.97 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.58 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loxoprofen SCHEMBL16166442 | 0.99 | PTGS1 (0.95) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL190158 | 0.99 | PTGS1 (0.95) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL11133884 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL28914092 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL28914090 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL14312087 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL28562194 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL24423 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL28562193 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL8754892 | 0.99 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2770 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4744679-A1 | USE OF POLYLACTIC ACID AND COPOLYMER THEREOF IN PREPARATION OF DRUGS FOR PROMOTING TENDON/LIGAMENT GROWTH | Changchun Sinobiomaterials Co., Ltd. (CN) | 2026-05-20 | — | — | EP | claimed |
| CN-122031449-A | External pharmaceutical composition containing loxoprofen and diclofenac | 第一三共健康事业株式会社 | 2026-05-15 | — | — | CN | claimed |
| US-20260130928-A1 | COMBINATION OF AKR1C3 ACTIVATED ANTICANCER PRODRUG COMPOUND AND ANALGESIC DRUG FOR TREATING CANCER PATIENTS ACCOMPANIED BY PAIN | ASCENTAWITS PHARMACEUTICALS LTD (CN) | 2026-05-14 | — | — | US | claimed |
| EP-4615506-A1 | USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES | Sahin, Fikret (TR) | 2025-09-17 | — | — | EP | claimed |
| CN-119837897-A | Tablet containing loxoprofen sodium and preparation method thereof | 山东中医药大学附属医院 | 2025-04-18 | — | — | CN | claimed |
| CN-119822949-A | Method for synthesizing loxoprofen sodium by using resin catalyst | 烟台舜康生物科技有限公司 | 2025-04-15 | — | — | CN | claimed |
| US-12257260-B2 | Pharmaceutical use of anemoside B4 against acute gouty arthritis | LIU QI (CN) | 2025-03-25 | — | — | US | claimed |
| CN-119185258-B | Loxoprofen sodium gel emplastrum and preparation method thereof | 博济医药科技股份有限公司 | 2025-03-21 | — | — | CN | claimed |
| CN-119552072-A | Chromatographic resolution method for 4 chiral isomers in loxoprofen sodium racemate | 浙江月旭材料科技有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-119385933-A | Loxoprofen sodium oral solution and preparation method thereof | 江西众泽源医药科技有限公司 | 2025-02-07 | — | — | CN | claimed |
| US-6248350-B1 | ANTIINFLAMMATORY ANALGESIC PATCH | LEAD CHEMICAL CO., LTD. (JP) | 2001-06-19 | — | — | US | claimed |
| CN-1294115-A | Process for preparing loxoprofen sodium | UNIV FUDAN (CN) | 2001-05-09 | — | — | CN | claimed |
| CN-1293954-A | Application of loxoprofen sodium in prepare medicines to treat gynopathy | UNIV FUDAN (CN) | 2001-05-09 | — | — | CN | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0386688-B1 | METHOD FOR PREPARING HYDROGEL PREPARATIONS AND XEROGEL PREPARATIONS | HOECHST JAPAN LIMITED (JP) | 1993-04-21 | — | — | EP | claimed |
| CN-1048659-A | The preparation method of aqueogel and xerogel preparation | HOECHST JAPAN (JP) | 1991-01-23 | — | — | CN | claimed |
| EP-0386688-A1 | Method for preparing hydrogel preparations and xerogel preparations | HOECHST JAPAN LIMITED (JP) | 1990-09-12 | — | — | EP | claimed |
| EP-0225005-B1 | ANTI-INFLAMMATORY ANALGESIC ADHESIVE PREPARATION | NITTO DENKO CORPORATION (JP) | 1990-03-14 | — | — | EP | claimed |
| US-4740374-A | Anti-inflammatory analgesic adhesive preparation | NITTO ELECTRIC INDUSTRIAL CO., LTD. (JP) | 1988-04-26 | — | — | US | claimed |
| EP-0225005-A1 | Anti-inflammatory analgesic adhesive preparation | NITTO DENKO CORPORATION (JP) | 1987-06-10 | — | — | EP | claimed |