Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loxoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 17/20 | 1.00 |
| ▸ | PTGS2 known ✓ | P35354 | 17/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.59 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loxoprofen SCHEMBL24423 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL28562193 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL28914090 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL28562194 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL28914092 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL11133884 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL14312087 | 1.00 | PTGS1 (1.00) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL33007 | 0.99 | PTGS1 (0.97) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL28213966 | 0.99 | PTGS1 (0.97) | PTGS1PTGS2OPRK1HTTKMT2A | |
| Loxoprofen SCHEMBL190158 | 0.97 | PTGS1 (0.95) | PTGS1PTGS2OPRK1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120128588-A1 | ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME | RIKEN (JP) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120128588-A1 | ISOTOPE LABELED 2-ARYLPROPIONIC ACID COMPOUNDS AND PROCESS FOR PRODUCTION OF SAME, AND MOLECULAR PROBE FOR POSITRON EMISSION TOMOGRAPHY AND METHOD FOR IMAGING OF CYCLOOXYGENASE AND THE LIKE USING SAME | CYP2F1, PTGS2, PTGER2 | PTGS1 5/4885PTGS2 2/4885OPRK1 1068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.