Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3297720 | 0.99 | HTR6 (0.52) | HTR6BRD4HTR3ASOS1RHEB | |
| SCHEMBL3297730 | 0.86 | HTR6 (0.56) | HTR6HTR3A | |
| SCHEMBL3299101 | 0.85 | HTR6 (0.53) | HTR6HTR3ASOS1 | |
| Hydrochloric Acid SCHEMBL3304362 | 0.85 | HTR6 (0.55) | HTR6HTR3A | |
| SCHEMBL3299796 | 0.85 | HTR6 (0.55) | HTR6HTR3A | |
| Hydrochloric Acid SCHEMBL3300697 | 0.84 | HTR6 (0.52) | HTR6HTR3ASOS1 | |
| SCHEMBL3296297 | 0.80 | BRD4 (0.45) | HTR6BRD4RHEB | |
| Hydrochloric Acid SCHEMBL3296557 | 0.80 | BRD4 (0.44) | BRD4RHEB | |
| SCHEMBL3296433 | 0.78 | HTR6 (0.60) | HTR6 | |
| Hydrochloric Acid SCHEMBL3297278 | 0.78 | HTR6 (0.59) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084131-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-08-05 | — | — | EP | claimed |
| WO-2008055808-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | claimed |
| US-7741326-B2 | for enhancing cognitive memory in an Alzheimer's patient; 5-HT2-selective and 5-HT6 selective ligands | ROCHE PALO ALTO LLC (US) | 2010-06-22 | — | — | US | disclosed |
| US-7741326-B2 | for enhancing cognitive memory in an Alzheimer's patient; 5-HT2-selective and 5-HT6 selective ligands | ROCHE PALO ALTO LLC (US) | 2010-06-22 | — | — | US | disclosed |
| US-7741326-B2 | for enhancing cognitive memory in an Alzheimer's patient; 5-HT2-selective and 5-HT6 selective ligands | ROCHE PALO ALTO LLC (US) | 2010-06-22 | — | — | US | disclosed |
| US-20080146587-A1 | Indole and benzofuran 2-carboxamide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
| US-20080146587-A1 | Indole and benzofuran 2-carboxamide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
| US-20080146587-A1 | Indole and benzofuran 2-carboxamide derivatives and uses thereof | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
| WO-2008055808-A1 | INDOLE AND BENZOFURAN 2-CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146587-A1 | Indole and benzofuran 2-carboxamide derivatives and uses thereof | AR, CNR2, CNR1 | HTR6 49/4885BRD4 48/4885HTR3A 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.