Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 6/20 | 0.39 |
| ▸ | CTSS | P25774 | 6/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13389317 | 1.00 | PPARA (0.40) | PPARACTSKCTSSCTSLCTSB | |
| SCHEMBL20170528 | 0.87 | CTSK (0.49) | PPARACTSKCTSSCTSLCTSB | |
| SCHEMBL18555427 | 0.87 | TDP1 (0.42) | PPARACTSKCTSSCTSLCTSB | |
| SCHEMBL18555424 | 0.87 | TDP1 (0.42) | PPARACTSKCTSSCTSLCTSB | |
| SCHEMBL15289799 | 0.87 | CTSK (0.49) | PPARACTSKCTSSCTSLCTSB | |
| SCHEMBL18555635 | 0.86 | PPARA (0.40) | PPARACTSKCTSSCTSLCTSB | |
| SCHEMBL18555637 | 0.86 | PPARA (0.40) | PPARACTSKCTSSCTSLCTSB | |
| SCHEMBL22772652 | 0.85 | MEN1 (0.48) | PPARACTSKCTSSCTSLCTSB | |
| SCHEMBL22772653 | 0.85 | MEN1 (0.48) | PPARACTSKCTSSCTSLCTSB | |
| SCHEMBL20905417 | 0.84 | PPARA (0.42) | PPARACTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8828993-B2 | Psychotropic agents having glutamate NMDA activity | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2014-09-09 | — | — | US | disclosed |
| US-20130131048-A1 | NOVEL PSYCHOTROPIC AGENTS HAVING GLUTAMATE NMDA ACTIVITY | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2013-05-23 | — | — | US | disclosed |
| US-8394790-B2 | Psychotropic agents having glutamate NMDA activity | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2013-03-12 | — | — | US | disclosed |
| US-20100093704-A1 | NOVEL PSYCHOTROPIC AGENTS HAVING GLUTAMATE NMDA ACTIVITY | RAMOT AT TEL-AVIV UNIVERSITY LTD (IL) | 2010-04-15 | — | — | US | disclosed |
| EP-2077860-A2 | NOVEL PSYCHOTROPIC AGENTS HAVING GLUTAMATE NMDA ACTIVITY | Ramot at Tel-Aviv University Ltd (IL) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008050341-A2 | NOVEL PSYCHOTROPIC AGENTS HAVING GLUTAMATE NMDA ACTIVITY | RAMOT AT TEL-AVIV UNIVERSITY LTD (IL) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130131048-A1 | NOVEL PSYCHOTROPIC AGENTS HAVING GLUTAMATE NMDA ACTIVITY | GRIN1, GRIN2A, GRIN2B | PPARA 1008/4885CTSK 2220/4885CTSS 2701/4885 |
| US-20100093704-A1 | NOVEL PSYCHOTROPIC AGENTS HAVING GLUTAMATE NMDA ACTIVITY | GRIN1, GRIN2A, GRIN2B | PPARA 1008/4885CTSK 2220/4885CTSS 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.