Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 4/20 | 0.59 |
| ▸ | IGF1R | P08069 | 13/20 | 0.59 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3300017 | 0.94 | IGF1R (0.60) | TNK2IGF1RNOS1NOS2ROCK2 | |
| SCHEMBL3303523 | 0.91 | IGF1R (0.57) | TNK2IGF1RROCK2PRKD3INSR | |
| SCHEMBL3296321 | 0.90 | IGF1R (0.72) | TNK2IGF1RROCK2PRKD3INSR | |
| SCHEMBL3296722 | 0.89 | IGF1R (0.63) | TNK2IGF1RROCK2PRKD3INSR | |
| SCHEMBL3299467 | 0.88 | IGF1R (0.62) | TNK2IGF1RROCK2PRKD3INSR | |
| SCHEMBL3296360 | 0.85 | IGF1R (0.68) | TNK2IGF1RROCK2PRKD3INSR | |
| SCHEMBL3299010 | 0.85 | IGF1R (0.66) | TNK2IGF1RROCK2PRKD3INSR | |
| SCHEMBL3299840 | 0.84 | IGF1R (0.60) | TNK2IGF1RROCK2PRKD3INSR | |
| SCHEMBL3298010 | 0.84 | IGF1R (0.57) | TNK2IGF1RROCK2PRKD3INSR | |
| SCHEMBL3299129 | 0.84 | IGF1R (0.57) | TNK2IGF1RROCK2PRKD3INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7741324-B2 | Imidazotriazines as protein kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2010-06-22 | — | — | US | claimed |
| EP-1781660-A1 | IMIDAZOPYRAZINE AS TYROSINE KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006012422-A1 | IMIDAZOPYRAZINE AS TYROSINE KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2006-02-02 | — | — | WO | claimed |
| US-20060019957-A1 | Imidazotriazines as protein kinase inhibitors | OSI PHARMACEUTICALS, INC. | 2006-01-26 | — | — | US | claimed |
| US-7741324-B2 | Imidazotriazines as protein kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2010-06-22 | — | — | US | disclosed |
| US-20060019957-A1 | Imidazotriazines as protein kinase inhibitors | OSI PHARMACEUTICALS, INC. | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019957-A1 | Imidazotriazines as protein kinase inhibitors | IGF1R, IRS1, INSR | TNK2 606/4885IGF1R 1/4885NOS1 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.