Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3302575 | 0.98 | KDM4E (0.56) | KDM4EPOLBRECQLHTTMAPT | |
| Bromide SCHEMBL3302576 | 0.98 | KDM4E (0.60) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL12849714 | 0.97 | KDM4E (0.57) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL13645489 | 0.87 | KDM4E (0.64) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL13686278 | 0.85 | KDM4E (0.62) | KDM4EPOLBRECQLBCHEACHE | |
| Bromide SCHEMBL5394060 | 0.83 | KDM4E (0.64) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL12201138 | 0.82 | KDM4E (0.59) | KDM4EPOLBRECQLHTTMAPT | |
| Bromide SCHEMBL10439579 | 0.81 | KDM4E (0.61) | KDM4EPOLBRECQLHTTSMN1; SMN2 | |
| SCHEMBL16450366 | 0.81 | KDM4E (0.57) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL19485776 | 0.81 | KDM4E (0.61) | KDM4EPOLBRECQLHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2993476-B1 | AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS | ENZO LIFE SCIENCES INC (US) | 2018-12-26 | — | — | EP | disclosed |
| EP-3001199-B1 | AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS | ENZO LIFE SCIENCES INC (US) | 2018-03-21 | — | — | EP | disclosed |
| EP-3001199-A1 | AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS | Enzo Life Sciences, Inc. (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2499495-B1 | Autophagy and phospholipidosis pathway assays | ENZO LIFE SCIENCES INC (US) | 2016-03-30 | — | — | EP | disclosed |
| EP-2993477-A1 | AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS | Enzo Life Sciences, Inc. (US) | 2016-03-09 | — | — | EP | disclosed |
| EP-2993476-A1 | AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS | Enzo Life Sciences, Inc. (US) | 2016-03-09 | — | — | EP | disclosed |
| US-9250249-B2 | Autophagy and phospholipidosis pathway assays | ENZO BIOCHEM, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| EP-2499495-A1 | AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS | Enzo Life Sciences, Inc. (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011031330-A1 | AUTOPHAGY AND PHOSPHOLIPIDOSIS PATHWAY ASSAYS | ENZO LIFE SCIENCES, INC. (US) | 2011-03-17 | — | — | WO | disclosed |
| US-20100093004-A1 | Autophagy and phospholipidosis pathway assays | ENZO LIFE SCIENCES, INC. | 2010-04-15 | — | — | US | disclosed |