Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28170910 | 0.82 | CYP3A4 (0.34) | CYP1A2USP2ALDH1A1CYP2C19MAPK1 | |
| SCHEMBL12045659 | 0.80 | CYP1A2 (0.43) | CYP1A2TDP1KDM4ESMN1; SMN2USP2 | |
| SCHEMBL3434463 | 0.76 | EPHX2 (0.55) | CYP1A2TDP1KDM4ESMN1; SMN2USP2 | |
| SCHEMBL26783934 | 0.75 | USP2 (0.60) | CYP1A2TDP1KDM4ESMN1; SMN2USP2 | |
| SCHEMBL23344999 | 0.75 | CYP1A2 (0.39) | CYP1A2TDP1KDM4ESMN1; SMN2USP2 | |
| SCHEMBL25628754 | 0.75 | CYP1A2 (0.39) | CYP1A2TDP1KDM4ESMN1; SMN2USP2 | |
| SCHEMBL12029857 | 0.75 | PIK3CD (0.40) | CYP1A2TDP1KDM4ESMN1; SMN2USP2 | |
| SCHEMBL18711878 | 0.74 | KDM4E (0.39) | CYP1A2TDP1KDM4ESMN1; SMN2USP2 | |
| SCHEMBL26807125 | 0.74 | HSD11B1 (0.39) | CYP1A2TDP1KDM4ESMN1; SMN2USP2 | |
| SCHEMBL15544126 | 0.73 | USP2 (0.58) | CYP1A2TDP1KDM4ESMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935254-A1 | COMPOUNDS OF 2,3-DIHYDRO-4H-1,3-BENZOXAZINE-4-ONE, METHOD FOR PREPARING THEM AND PHARMACEUTICAL FORM COMPRISING THEM | C4T S.C. a.r.l. (IT) | 2015-10-28 | — | — | EP | disclosed |
| EP-2114951-B9 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2015-09-02 | — | — | EP | disclosed |
| EP-2114951-B9 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2015-09-02 | — | — | EP | disclosed |
| WO-2014097188-A1 | COMPOUNDS OF 2,3-DIHYDRO-4H-1,3-BENZOXAZINE-4-ONE, METHOD FOR PREPARING THEM AND PHARMACEUTICAL FORM COMPRISING THEM | C4T S.C. A.R.L. (IT) | 2014-06-26 | — | — | WO | disclosed |
| CN-101631792-B | Novel phosphodiesterase inhibitors | LEO PHARMA AS DK | 2013-05-01 | — | — | CN | disclosed |
| US-8338431-B2 | Phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2012-12-25 | — | — | US | disclosed |
| US-8338431-B2 | Phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2012-12-25 | — | — | US | disclosed |
| US-8338431-B2 | Phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2012-12-25 | — | — | US | disclosed |
| US-20100099688-A1 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2010-04-22 | — | — | US | disclosed |
| US-20100099688-A1 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2010-04-22 | — | — | US | disclosed |
| US-20100099688-A1 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2010-04-22 | — | — | US | disclosed |
| CN-101631792-A | Novel phosphodiesterase inhibitors | LEO PHARMA AS | 2010-01-20 | — | — | CN | disclosed |
| EP-2114951-A2 | NOVEL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008104175-A2 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2008-09-04 | — | — | WO | disclosed |
| WO-2008104175-A2 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2008-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099688-A1 | NOVEL PHOSPHODIESTERASE INHIBITORS | PDE3A, PDE5A, PDE3B | CYP1A2 185/4885TDP1 32/4885KDM4E 1235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.