Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.86 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.70 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.67 |
| ▸ | CTSL | P07711 | 2/20 | 0.66 |
| ▸ | APP | P05067 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30383825 | 1.00 | CYP19A1 (0.86) | CYP19A1ABCG2FLT3PTPN1CTSL | |
| SCHEMBL3304114 | 1.00 | CYP19A1 (0.86) | CYP19A1ABCG2FLT3PTPN1CTSL | |
| SCHEMBL3307506 | 0.93 | CYP19A1 (1.00) | CYP19A1ABCG2FLT3PTPN1CTSL | |
| SCHEMBL3307514 | 0.93 | CYP19A1 (1.00) | CYP19A1ABCG2FLT3PTPN1CTSL | |
| SCHEMBL30383105 | 0.93 | CYP19A1 (1.00) | CYP19A1ABCG2FLT3PTPN1CTSL | |
| SCHEMBL30384003 | 0.92 | CYP19A1 (0.80) | CYP19A1ABCG2FLT3PTPN1CTSL | |
| SCHEMBL3305507 | 0.92 | CYP19A1 (0.80) | CYP19A1ABCG2FLT3PTPN1CTSL | |
| SCHEMBL3305503 | 0.92 | CYP19A1 (0.80) | CYP19A1ABCG2FLT3PTPN1CTSL | |
| SCHEMBL30383478 | 0.91 | PTPN1 (0.79) | CYP19A1ABCG2FLT3PTPN1CTSL | |
| SCHEMBL3307176 | 0.91 | PTPN1 (0.79) | CYP19A1ABCG2FLT3PTPN1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946287-B2 | Chemotherapeutic flavonoids, and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946287-B2 | Chemotherapeutic flavonoids, and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946287-B2 | Chemotherapeutic flavonoids, and syntheses thereof | PURDUE RESEARCH FOUNDATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-20100099755-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2010-04-22 | — | — | US | disclosed |
| US-20100099755-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2010-04-22 | — | — | US | disclosed |
| US-20100099755-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2010-04-22 | — | — | US | disclosed |
| WO-2008076767-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076767-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099755-A1 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF | NRAS, FAU, DPYD | CYP19A1 104/4885ABCG2 7/4885FLT3 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.