Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31218507 | 0.69 | CHRM2 (0.44) | HDAC1HDAC6ESR2USP2SMN1; SMN2 | |
| SCHEMBL4796997 | 0.68 | CHRM2 (0.43) | HDAC1HDAC6ESR2USP2SMN1; SMN2 | |
| SCHEMBL30884530 | 0.67 | PIK3CA (0.40) | PIK3CAMTORGAADRD2SMN1; SMN2 | |
| SCHEMBL4790633 | 0.67 | KLK7 (0.34) | NFKB1NFKB2RELAL3MBTL1 | |
| SCHEMBL25047142 | 0.66 | HDAC1 (0.34) | HDAC1HDAC6ESR2USP2SMN1; SMN2 | |
| SCHEMBL21055130 | 0.66 | ESR2 (0.53) | PIK3CAMTORHDAC1ESR2NR1H2 | |
| SCHEMBL29314279 | 0.66 | CHRM2 (0.33) | HDAC1HDAC6L3MBTL1ESR2USP2 | |
| SCHEMBL13391275 | 0.65 | NFKB1 (0.42) | NFKB1NFKB2RELAHDAC1HDAC6 | |
| SCHEMBL29314278 | 0.65 | HDAC1 (0.34) | HDAC1HDAC6ESR2USP2SMN1; SMN2 | |
| SCHEMBL26627533 | 0.65 | ESR2 (0.37) | ESR2USP2SMN1; SMN2NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592587-B2 | Transannular rearrangement of activated lactams | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2013-11-26 | — | — | US | disclosed |
| EP-2134681-B1 | TRANS-ANNULAR REARRANGEMENT OF ACTIVE LACTAMES | CENTRE NAT RECH SCIENT (FR) | 2012-05-16 | — | — | EP | disclosed |
| US-20100099874-A1 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) | 2010-04-22 | — | — | US | disclosed |
| US-20100099874-A1 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) | 2010-04-22 | — | — | US | disclosed |
| US-20100099874-A1 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS (FR) | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099874-A1 | TRANSANNULAR REARRANGEMENT OF ACTIVATED LACTAMS | C9, RPS4Y1, C5 | LIPE 2910/4885PIK3CA 1281/4885MTOR 421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.