Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dorzolamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 18/20 | 1.00 |
| ▸ | CA1 | P00915 | 3/20 | 1.00 |
| ▸ | CA12 | O43570 | 1/20 | 1.00 |
| ▸ | CA3 | P07451 | 1/20 | 1.00 |
| ▸ | AR | P10275 | 1/20 | 1.00 |
| ▸ | CA4 | P22748 | 1/20 | 1.00 |
| ▸ | CA6 | P23280 | 1/20 | 1.00 |
| ▸ | CA5A | P35218 | 1/20 | 1.00 |
| ▸ | CA7 | P43166 | 1/20 | 1.00 |
| ▸ | CA9 | Q16790 | 1/20 | 1.00 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 1.00 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 1.00 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dorzolamide SCHEMBL9914274 | 1.00 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL4525137 | 1.00 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL24061 | 1.00 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL12453422 | 1.00 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL12874119 | 1.00 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL4455530 | 1.00 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL12223216 | 1.00 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL9914275 | 1.00 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL3314050 | 0.99 | CA2 (0.98) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL28388851 | 0.99 | CA2 (0.98) | CA2CA1CA12CA3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010061398-A1 | PROCESS FOR PREPARING DORZOLAMIDE HYDROCHLORIDE AND ITS INTERMEDIATE | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-06-03 | — | — | WO | claimed |
| US-6313155-B1 | Composition and method for treating macular disorders | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2001-11-06 | — | — | US | claimed |
| EP-0296879-B1 | SUBSTITUTED AROMATIC SULFONAMIDES AS ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1993-03-17 | — | — | EP | claimed |
| EP-0296879-A1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-28 | — | — | EP | claimed |
| JP-1100174-A | — | — | None | — | — | JP | disclosed |
| JP-6298767-A | — | — | None | — | — | JP | disclosed |
| CN-111233887-A | Synthesis process of dorzolamide hydrochloride intermediate | 武汉武药科技有限公司 | 2020-06-05 | — | — | CN | disclosed |
| US-9481686-B2 | Process for preparing enantiomerically enriched oxamides | ZACH SYSTEM S.P.A. (IT) | 2016-11-01 | — | — | US | disclosed |
| US-9481686-B2 | Process for preparing enantiomerically enriched oxamides | ZACH SYSTEM S.P.A. (IT) | 2016-11-01 | — | — | US | disclosed |
| EP-3057576-A1 | PRESERVATIVE-FREE OPHTHALMIC PHARMACEUTICAL FORMULATION | Sentiss Pharma Private Limited (IN) | 2016-08-24 | — | — | EP | disclosed |
| CN-103497202-B | The synthetic method of dorzolamide hydrochloride intermediate | WUHAN WUYAO SCIENCE & TECHNOLOGY Co.,Ltd. (CN) | 2015-12-02 | — | — | CN | disclosed |
| CN-103497202-B | The synthetic method of dorzolamide hydrochloride intermediate | WUHAN WUYAO SCIENCE & TECHNOLOGY Co.,Ltd. (CN) | 2015-12-02 | — | — | CN | disclosed |
| EP-0296879-B1 | SUBSTITUTED AROMATIC SULFONAMIDES AS ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| WO-1991015206-A1 | TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION WITH IMIDAZOLE ANGIOTENSIN-II RECEPTOR ANTAGONISTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-10-17 | — | — | WO | disclosed |
| US-4863922-A | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use | MERCK & CO., INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4824968-A | REMOVING HYDROXYL GROUP WITH SODIUM IODIDE AND DICHLORODIMETHYLSILANE IN ACETONITRILE | MERCK & CO., INC. (US) | 1989-04-25 | — | — | US | disclosed |
| JP-H01100174-A | SUBSTITUTED AROMATIC SULFONAMIDE AS ANTIGLAUCOMA AGENT | MERCK & CO INC | 1989-04-18 | — | — | JP | disclosed |
| US-4820848-A | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO., INC. (US) | 1989-04-11 | — | — | US | disclosed |
| US-4797413-A | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use | MERCK & CO., INC. (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0296879-A1 | Substituted aromatic sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-28 | — | — | EP | disclosed |