Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.62 |
| ▸ | PLK4 | O00444 | 4/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 3/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | YES1 | P07947 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14354061 | 0.88 | DGAT1 (0.48) | JAK2PLK4INSRJAK3PTK2 | |
| SCHEMBL3301223 | 0.83 | KDR (0.52) | JAK2JAK3PTK2ABL1KDR | |
| SCHEMBL2144948 | 0.82 | JAK2 (0.74) | JAK2PLK4INSRJAK3PTK2 | |
| SCHEMBL28254694 | 0.77 | JAK2 (1.00) | JAK2PLK4JAK3PTK2KDR | |
| SCHEMBL3195106 | 0.77 | JAK2 (0.67) | JAK2INSRJAK3PTK2MAPK8 | |
| SCHEMBL15273104 | 0.76 | TTK (0.52) | JAK2PLK4INSRJAK3PTK2 | |
| SCHEMBL3305445 | 0.75 | JAK2 (0.44) | JAK2JAK3PTK2KDR | |
| SCHEMBL15268777 | 0.75 | JAK2 (0.57) | JAK2PLK4INSRJAK3PTK2 | |
| SCHEMBL2145013 | 0.74 | JAK2 (0.73) | JAK2INSRJAK3PTK2TP53 | |
| SCHEMBL3204359 | 0.74 | JAK2 (0.72) | JAK2PLK4INSRJAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093698-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093698-A1 | AMINOTRIAZOLOPYRIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | MAP3K2, MAP3K1, MAP3K3 | JAK2 26/4885PLK4 324/4885INSR 1211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.