Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3307921 | 0.81 | TSHR (0.47) | TSHRRECQLHCRTR1HCRTR2BCAT2 | |
| SCHEMBL3307922 | 0.80 | TSHR (0.46) | TSHRRECQLHCRTR1HCRTR2BCAT2 | |
| SCHEMBL3314868 | 0.72 | HCRTR1 (0.41) | TSHRRECQLHCRTR1HCRTR2LMNA | |
| SCHEMBL3309753 | 0.72 | SLC6A4 (0.42) | TSHRRECQLHCRTR1HCRTR2BCAT2 | |
| SCHEMBL202879 | 0.71 | ACE (0.44) | LMNA | |
| SCHEMBL3311710 | 0.71 | HCRTR1 (0.45) | TSHRRECQLHCRTR1HCRTR2LMNA | |
| SCHEMBL3318857 | 0.71 | HCRTR1 (0.40) | TSHRRECQLHCRTR1HCRTR2LMNA | |
| SCHEMBL3312345 | 0.70 | CDK4 (0.42) | TSHRRECQLHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL3318429 | 0.70 | MMP9 (0.42) | HCRTR1HCRTR2GAASMN1; SMN2NPSR1 | |
| SCHEMBL3318435 | 0.69 | POLB (0.40) | HCRTR1HCRTR2LMNAALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236964-B2 | Thiazolidine derivatives as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-08-07 | — | — | US | disclosed |
| US-20100113531-A1 | THIAZOLIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113531-A1 | THIAZOLIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | HCRTR1, HCRTR2, NPY1R | TSHR 37/4885RECQL 3949/4885HCRTR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.