Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | LITAF | Q99732 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3312312 | 0.86 | MEN1 (0.46) | ALDH1A1NPSR1POLBKDM4EL3MBTL1 | |
| SCHEMBL13332515 | 0.85 | OPRL1 (0.37) | ALDH1A1NPSR1POLBKDM4EL3MBTL1 | |
| SCHEMBL13332400 | 0.83 | ALDH1A1 (0.62) | ALDH1A1NPSR1POLBKDM4EL3MBTL1 | |
| SCHEMBL3311905 | 0.79 | NPSR1 (0.36) | ALDH1A1NPSR1POLBKDM4EL3MBTL1 | |
| SCHEMBL13332744 | 0.77 | MEN1 (0.46) | ALDH1A1NPSR1POLBKDM4EL3MBTL1 | |
| SCHEMBL13332713 | 0.77 | KMT2A (0.42) | ALDH1A1NPSR1POLBKDM4EL3MBTL1 | |
| SCHEMBL13332465 | 0.77 | KMT2A (0.42) | ALDH1A1POLBKDM4EL3MBTL1TSHR | |
| SCHEMBL13332991 | 0.76 | MEN1 (0.43) | ALDH1A1NPSR1POLBKDM4EL3MBTL1 | |
| SCHEMBL13332988 | 0.76 | MEN1 (0.41) | ALDH1A1NPSR1POLBKDM4EL3MBTL1 | |
| SCHEMBL13332461 | 0.76 | KMT2A (0.43) | ALDH1A1POLBKDM4EL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113391-A1 | BICYCLIC HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2010-05-06 | — | — | US | disclosed |
| EP-2138482-A1 | BICYCLIC HETEROCYCLIC COMPOUND | Astellas Pharma Inc. (JP) | 2009-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113391-A1 | BICYCLIC HETEROCYCLIC COMPOUND | P2RY12, P2RY4, P2RY1 | ALDH1A1 1350/4885NPSR1 313/4885POLB 3950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.