Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.64 |
| ▸ | CDK2 | P24941 | 4/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.57 |
| ▸ | EGFR | P00533 | 10/20 | 0.57 |
| ▸ | INSR | P06213 | 2/20 | 0.53 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.53 |
| ▸ | CCNK | O75909 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.53 |
| ▸ | CCNH | P51946 | 1/20 | 0.53 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2347443 | 0.92 | IGF1R (0.69) | IGF1RCDK2KCNH2EGFRINSR | |
| SCHEMBL2344345 | 0.84 | IGF1R (0.65) | IGF1RCDK2KCNH2EGFRINSR | |
| SCHEMBL2342901 | 0.84 | IGF1R (0.65) | IGF1RCDK2KCNH2EGFRINSR | |
| SCHEMBL3313620 | 0.84 | IGF1R (0.84) | IGF1RCDK2KCNH2EGFRCYP3A4 | |
| SCHEMBL2349113 | 0.84 | IGF1R (0.70) | IGF1RCDK2KCNH2EGFRINSR | |
| SCHEMBL2349062 | 0.83 | IGF1R (0.66) | IGF1RCDK2KCNH2EGFRINSR | |
| SCHEMBL2346628 | 0.83 | EGFR (0.67) | IGF1RCDK2KCNH2EGFRCDK7 | |
| SCHEMBL3310189 | 0.83 | EGFR (0.67) | IGF1RCDK2KCNH2EGFRCDK7 | |
| SCHEMBL3349646 | 0.83 | EGFR (0.67) | IGF1RCDK2KCNH2EGFRCDK7 | |
| SCHEMBL2354282 | 0.83 | IGF1R (0.74) | IGF1RCDK2KCNH2EGFRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | IGF1R 4384/4885CDK2 64/4885KCNH2 3082/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.