Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317820 | 1.00 | PARP15 (0.46) | PARP15PARP10CHRNB4CHRNA3FAAH | |
| SCHEMBL13362068 | 0.91 | PARP15 (0.46) | PARP15PARP10CHRNB4CHRNA3FAAH | |
| SCHEMBL3313710 | 0.91 | CHRNB4 (0.44) | PARP15PARP10CHRNB4CHRNA3FAAH | |
| SCHEMBL3313944 | 0.91 | CHRNB4 (0.44) | PARP15PARP10CHRNB4CHRNA3FAAH | |
| SCHEMBL3315730 | 0.86 | ALOX5AP (0.47) | PARP15PARP10CHRNB4CHRNA3FAAH | |
| SCHEMBL3315725 | 0.86 | ALOX5AP (0.47) | PARP15PARP10CHRNB4CHRNA3FAAH | |
| SCHEMBL13849433 | 0.82 | CHRNB4 (0.66) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL13362025 | 0.82 | CHRNB4 (0.44) | PARP15PARP10CHRNB4CHRNA3FAAH | |
| SCHEMBL4534956 | 0.81 | CHRNB4 (0.53) | CHRNB4CHRNA3CHRNB2CHRNA4HTR4 | |
| SCHEMBL28159876 | 0.78 | FFAR1 (0.53) | CHRNB4CHRNA3CHRNB2CHRNA4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | PARP15 358/4885PARP10 479/4885CHRNB4 4417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.