Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.67 |
| ▸ | CDK2 | P24941 | 9/20 | 0.67 |
| ▸ | INSR | P06213 | 1/20 | 0.67 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | CDK7 | P50613 | 1/20 | 0.57 |
| ▸ | CDK9 | P50750 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318798 | 0.90 | IGF1R (0.77) | IGF1RKCNH2CDK2INSR | |
| SCHEMBL3315426 | 0.87 | IGF1R (0.81) | IGF1RKCNH2CDK2INSR | |
| SCHEMBL3313159 | 0.86 | IGF1R (0.68) | IGF1RKCNH2CDK2INSRCDK1 | |
| SCHEMBL3317259 | 0.86 | IGF1R (0.70) | IGF1RKCNH2CDK2INSRCDK1 | |
| SCHEMBL3317085 | 0.85 | IGF1R (0.78) | IGF1RKCNH2CDK2INSR | |
| SCHEMBL3314650 | 0.84 | IGF1R (0.72) | IGF1RKCNH2CDK2INSR | |
| SCHEMBL3313036 | 0.83 | IGF1R (0.81) | IGF1RKCNH2CDK2INSR | |
| SCHEMBL3314148 | 0.82 | IGF1R (0.72) | IGF1RKCNH2CDK2INSR | |
| SCHEMBL3316979 | 0.82 | IGF1R (0.74) | IGF1RKCNH2CDK2INSR | |
| SCHEMBL13362116 | 0.81 | IGF1R (0.80) | IGF1RKCNH2CDK2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | claimed |
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | IGF1R 4384/4885KCNH2 3082/4885CDK2 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.